硒对高碘大鼠TGAb、TMAb、FT_3、FT_4和TSH影响的观察  

Effect of selenium on serum TGAb,TMAb,FT_3,FT_4 and TSH of rats with excessive intake of iodine

作　　者：迟海燕[1] 周玉萍[1] 李莉[1] 

机构地区：[1]威海市立医院内分泌科,威海264200

出　　处：《卫生研究》2012年第4期540-542,共3页Journal of Hygiene Research

摘　　要：目的探讨硒对高碘摄入大鼠甲状腺TGAb、TMAb、FT3、FT4和TSH的影响。方法 Wistar大鼠随机分为对照组、高碘组和高碘加硒组,高碘加硒组灌胃给予亚硒酸钠,观察各组血清TGAb、TMAb、FT3、FT4和TSH水平变化。结果各组实验前后血清FT3、FT4和TSH水平差异无显著性(P>0.05),高碘组两种抗体水平逐渐缓慢升高,自身前后对比差异有显著性(P<0.05),而高碘加硒组抗体水平变化不大(P>0.05)。结论高碘组大鼠血清自身抗体水平随着时间的延长逐步升高,而硒对此有拮抗作用。Objective To investigate the effect of selenium on the TGAb, TMAb, FT3 ,FT4 and TSH level of rats with excessive intake of iodine. Methods Wistar rats were divided into three groups by random：normal control, high iodine group and high iodine plus selenium group. Rats in the high iodine plus selenium group were lavaged with sodium selenite for 10 weeks. The levels of serum TGAb,TMAb, FT3 ,FT4 and TSH were tested at different time of the experiment. Results There were no significant change on levels of FT3, FT4 and TSH （P 〉 0. 05）. The levels of TGAb and TMAb in the high iodine group were inereased slowly （P 〈0. 05） , but no significant change was observed in the high iodine plus selenium group. Conclusion Exeessive intake of iodine might induee goiter, and selenium might have antagonistic effect on it.

关 键 词：碘 硒 甲状腺 

分 类 号：Q58[生物学—生物化学]