黄连紫草膏中地黄、紫草的醇提工艺优选  

Optimization of Ethanol Extraction Technology for Rehmannia glutinosa and Arnebia euchroma from Huanglian Zicao Gel

作　　者：刘丽花[1] 翟来超[1] 陈天朝[1] 

机构地区：[1]河南中医学院第一附属医院药学部,郑州450000

出　　处：《中国实验方剂学杂志》2012年第15期35-38,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：河南中医学院院级课题(2008kj14)

摘　　要：目的:优选黄连紫草膏中地黄、紫草的提取工艺。方法:以梓醇、毛蕊花糖苷、紫草素的含量和干膏得率为指标,考察乙醇体积分数、提取时间、乙醇用量、提取次数对提取工艺的影响,通过层次分析法确定各指标的权重系数,均匀设计优选醇提工艺。结果:最佳提取工艺为12倍量65%乙醇提取2 h。结论:该优选工艺稳定可行,可为提取工艺的确定和剂型改革提供依据。Objective：To optimize extraction technology of Rehmannia glutinosa and Arnebia euchroma from Huanglian Zicao gel.Method： With the content of the catalpol,verbascoside and shikonin,yield of dry extract as indexes,to investigate influence of ethanol concentration,extraction time,ethanol dosage and extraction times on extraction process,weight coefficient of indexes were determined by analytic hierarchy process,ethanol extraction technology was optimized by uniform design method.Result： The best extraction process was：extracted 2 h with 12 times the amount of 65% ethanol.Conclusion： This optimized technology was stable and feasible,it could provide basis for determination of extraction technology and formulations reformation.

关 键 词：层次分析法 均匀试验 醇提工艺 紫草 地黄 

分 类 号：R283.6[医药卫生—中药学]