白芷、石菖蒲对冲和膏处方中主要成分经皮渗透作用的影响  

Influence of Angelica dahurica and Acorus tatarinowii on Transdermal Permeation Role of Active Ingredients from Chonghe Gel Prescription

作　　者：王亚静[1] 孙士真[1] 张德芹[1] 田慧[1] 彭淑娟[1] 王艳明[1] 

机构地区：[1]天津中医药大学天津市现代中药重点实验室-省部共建国家重点实验室培育基地,天津300193

出　　处：《中国实验方剂学杂志》2012年第15期38-41,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：天津市高校双五科技计划项目(SW20080007)

摘　　要：目的:考察佐使药白芷、石菖蒲对冲和膏中主要成分经皮渗透的影响。方法:采用改良Franz透皮扩散池,大鼠离体皮肤为渗透屏障,以芍药苷和蛇床子素为指标,HPLC测定其含量,分别考察白芷、石菖蒲及其配伍联用对冲和膏主要成分促透作用的影响。结果:白芷、石菖蒲单用对芍药苷经皮渗透的增渗倍数分别为0.84,1.02,对蛇床子素的增渗倍数分别为1.54,0.79;配伍联用后芍药苷和蛇床子素的经皮渗透均达到最佳水平,增渗倍数分别1.00,1.89。结论:白芷、石菖蒲配伍联用可促进主要成分的经皮渗透,对冲和膏处方药效的发挥具有重要的佐使作用。Objective： To investigate effect of Angelica dahurica and Acorus tatarinowii on in vitro percutaneous permeation of active ingredients from Chonghe gel.Method： Improved Franz-type diffusion cell was used,with isolated rat skin as transdermal barrier,with the content of paeoniflorin and osthole as indexes which was determined by HPLC,effect of A.dahurica,A.tatarinowii alone and their compatibility combination on promote transparent role of main ingredients from Chonghe gel were investigated,respectively.Result： Enhancement ratios（ER） of A.dahurica and A.tatarinowii alone on percutaneous penetration of peoniflorin were 0.84,1.02,while ER of osthole were 1.54,0.79.Percutaneous penetration role of peoniflorin and osthole by compatibility combination of A.dahurica and A.tatarinowii could reach optimum level,ER of peoniflorin and osthole were 1.00,1.89.Conclusion： A.dahurica and A.tatarinowii used jointly could benefit to transdermal permeation of active ingredients,which had important role on therapeutic effect of Chonghe gel.

关 键 词：白芷 石菖蒲 经皮渗透 芍药苷 蛇床子素 冲和膏 

分 类 号：R283.6[医药卫生—中药学]