血栓心脉宁片挥发油化学成分的GC-MS分析  

Chemical Costituents in Volatile Oil from Xueshuan Xinmaining Tablet with GC-MS Analysis

作　　者：刘金平[1] 明磊[1] 刘海宇[1] 张庆贺[1] 林美妤[1] 刘传贵[1] 李平亚[1] 卢丹[1] 

机构地区：[1]吉林大学再生医学科学研究所,长春130021

出　　处：《中国实验方剂学杂志》2012年第15期93-95,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:分析比较不同批次血栓心脉宁片挥发油化学成分。方法:采用水蒸气蒸馏法提取挥发油,应用GC-MS分析鉴定了血栓心脉宁片挥发油的化学成分,面积归一化法测定其相对含量。结果:从批号110603药品中分离得到42个色谱峰,鉴定了其中36个化合物,主要成分为龙脑(43.25%)、异龙脑(30.03%)及麝香酮(7.95%)。从批号110309药品中分离得到40个色谱峰,鉴定了其中33个化合物,主要成分为龙脑(43.37%)、异龙脑(30.14%)及麝香酮(7.71%)。结论:两个批次的血栓心脉宁片挥发油化学成分基本一致,表明该药性质稳定。该方法简便、快速、重复性好,为血栓心脉宁片质量评价提供了一定的科学依据。Objective： To analyze the chemical constituents of volatile oil extracted from Xueshuan Xinmaining tablet.Method： Volatile oil was extracted by water-steam distillation.The components were quantitatively determined with normalization method,and were identified by GC-MS.Results： Forty-two compounds were separated by GC from batch of 110603 and 36 of them were identified.The major components were borneol（43.25%）,isoborneol（30.03%）and muscone（7.95%）.40 compounds were separated by GC from 110309 and 33 of them were identified.The major components were borneol（43.37%）,isoborneol（30.14%）and muscone（7.71%）.Conclusion： The chemical components in volatile oils were basically same in two samples,so the medicine is stable.The method is simple and rapid with good repeatability.It will provide theoretical foundation for its quality evaluation and clinical medication.

关 键 词：血栓心脉宁片 气相色谱-质谱联用仪 龙脑 异龙脑 麝香酮 

分 类 号：R284.1[医药卫生—中药学]