奥曲肽对重症急性胰腺炎患者血浆中D-二聚体及VEGF的影响  

Influence of octreotide on plasma D-dimer and WEGF in patients with severe acute pancreatitis

作　　者：杨远征[1] 陈勉[1] 林尤冠[2] 饶平[1] 胡志华[1] 

机构地区：[1]海南医学院附属医院重症病房,海南海口570102 [2]海南医学院附属医院消化科,海南海口570102

出　　处：《海南医学院学报》2012年第9期1253-1255,共3页Journal of Hainan Medical University

基　　金：中国高校医学期刊临床专项资金项目(112210305)~~

摘　　要：目的:探讨奥曲肽对重症急性胰腺炎患者血浆中D-二聚体、血管内皮生长因素(VEGF)的影响及其二者相关性。方法:98例重症急性胰腺炎患者随机分为对照组(49例)和观察组(49例),两组均采用常规治疗,观察组加用奥曲肽,对照组加用国产生长抑素,对比两组患者临床疗效和治疗前、后血浆中D-二聚体及VEGF的水平变化,并分析二者相关性。结果:观察组临床疗效明显优于对照组,两组间比较差异有统计学意义(P<0.05);血浆中D-二聚体、VEGF治疗前均显著升高,治疗后均下降,两组治疗前、后差异均有统计学意义(P<0.01);治疗后两组D-二聚体、VEGF水平比较,差异均有统计学意义(P<0.01);D-二聚体、VEGF水平在治疗前、后均有相关性(P<0.01)。结论:D-二聚体、VEGF可作为重症急性胰腺炎治疗效果的指标,可判定预后。Objective： To investigate the influence of octreotide on plasma D-dimer and VEGF in severe acute pancreatitis patients, and to explore the correlation of the two. Methods： A total of 98 cases of severe acute pancreatitiS were randomly divided into control group （49 cases） and observation group （49 cases）. The observation group was given conventional therapy ＋ octreotide, while the control group was given conventional therapy ＋ somatostatin, clinical efficacy and plasma D-dimer and VEGF levels before and after treatment were observed and compared between the two groups. Results：The clinical efficacy of the observation group was significant better than that of the control group （P〈0.05） ; The increased plasma D--dimer and VEGF were significantly decreased after treatment in both groups （P〈0.05）. But after treatment, plasma D-dimer and VEGF were significant different between the two groups （P〈0.05）. The D-dimer andVEGF levels were correlated with each other （P〈0.01）. Conclusions： D-dimer, VEGF can be used as the indicators for evaluating treatment effects of severe acute pancreatitis.

关 键 词：奥曲肽 重症急性胰腺炎 D-二聚体 血管内皮生长因素(VEGF) 

分 类 号：R657.51[医药卫生—外科学]