肥胖型多囊卵巢综合征的减重效应观察  

Weight loss effect of metformin on obese polycystic ovary syndrome

作　　者：李雅琪[1] 廖国芳[1] 彭俊[1] 宋致蓉 马燕[1] 张瑜[1] 杨炜婷 罗连英[1] 温芯 

机构地区：[1]凉山州第一人民医院妇产科,四川西昌615000

出　　处：《海南医学院学报》2012年第9期1271-1273,共3页Journal of Hainan Medical University

基　　金：中国高校医学期刊临床专项资金项目(112210314)~~

摘　　要：目的:探讨减重训练及口服二甲双胍对肥胖型多囊卵巢综合征的短期疗效。方法:对肥胖型多囊卵巢综合征患者进行减重训练及口服二甲双胍减重治疗,测定减重前、后相关性激素指标、糖代谢指标、体重变化情况等。结果:减重前、后FSH、E2、P、PRL、GLU无明显变化(P>0.05),LH、T、LH/FSH、INS明显下降(P<0.05);AUC(葡萄糖)、AUC(胰岛素)、HOMA-IR明显下降(P<0.05);体重指数及腰臀比下降。结论:减重治疗可纠正多囊卵巢综合征内分泌紊乱,是一种恢复排卵及月经周期的经济治疗方法。Objective. To discuss short-term curative effect of metformin and weight training on obese polycystic ovary syndrome. Methods. Obese patients with polycystie ovary syndrome underwent weight training and oral administration of metformin, then weight change, relative hormone indexes, and indices of glucose metabolism were observed and compared between these before and after treatment. Results： There was no significant change in FSH, E2, P, PRL and GLU after treatment （P〉0.05）,while LH, T, LH/FSH, INS decreased significantly （P〈0.05） ; AUC （glucose）, AUC （insulin）, HOMA-IR also decreased significantly （P〈0.05） ; body mass index and waist-hip ratio were： declined. Conclusions： Weight reduction treatment can correct endocrine disorders, and is an effective treatment for resumption of ovulation and menstrual cycle.

关 键 词：肥胖型多囊卵巢综合征 减重训练 二甲双胍 

分 类 号：R711.75[医药卫生—妇产科学]