10种中药水煎剂对念珠菌的体外抑菌作用  

In Vitro Fungistasis of Ten Chinese Drug Decoctions against Candida

作　　者：刘涛峰[1] 郑玉荣[1] 刘小平[1] 张虹亚[1] 王建锋[1] 孙洪波[1] 吴敏[1] 曹宇[1] 何素敏[1] 

机构地区：[1]安徽中医学院第一附属医院皮肤科,安徽合肥230031

出　　处：《安徽中医学院学报》2012年第4期72-74,共3页Journal of Anhui Traditional Chinese Medical College

基　　金：安徽中医学院临床科学研究基金项目(2010LC-031A)

摘　　要：目的观察苦参、土槿皮、黄柏、百部、黄连、虎杖、黄芩、大黄、藿香、五倍子及其混合液体外抑制念珠菌的效果。方法参照1997年美国国家临床实验标准化委员会M27-A方案中的酵母菌微量稀释法进行药敏试验。结果同一种中药水煎剂及不同的单味中药水煎剂对不同的念珠菌标准菌株的最低抑菌浓度(minimuminhibitory concentration,MIC)各不相同,中药混合液对5种标准菌株的MIC最低,均≤0.031 25g/ml。结论不同的中药对不同的念珠菌的抑制作用各不相同,复方对念珠菌的抑制作用优于单味中药。Objective To observe the in vitro fungistasis of ten decoctions of Chinese drugs, lightyellow sophora root, pseudolarix, amoorcorn tree bark, stemona root, golden thread, giant knotweed rhizome, baical skullcap root, rhubarb, agastache rugosa, Chinese gall, and their compound decoction against Candida. Methods The in vitro drug sensitive test for candida was performed using liquid microdilution method in M27-A Scheme released by American National Committee Clinical Laboratory Standards. Results The mini- mum inhibitory concentrations （MICs） of the same Chinese drug decoction and different Chinese drug decoctions a- gainst different standard strains of Candida were different, and the MICs of compound decoction against five stand- ard strains of Candida were the lowest, being less than 0. 031 25 g/ml. Conclusion The fungistasis of different Chinese drugs against different strains of Candida is different, and the inhibitive effects of compound de- coction against Candida are superior to those of single Chinese drug decoction.

关 键 词：念珠菌 中药水煎剂 抑真菌作用 液基微量稀释法 

分 类 号：R379.4[医药卫生—病原生物学]