我院2006-2010年临床分离大肠埃希菌和肺炎克雷伯菌的耐药性分析  

Drug Resistance of Clinical Isolated Escherichia Coli and Klebsiella Pneumoniae in Our Hospital during 2006-2010

作　　者：汝玲[1] 

机构地区：[1]海南省人民医院药学部,海口570311

出　　处：《中国药房》2012年第30期2841-2844,共4页China Pharmacy

摘　　要：目的:分析我院大肠埃希菌和肺炎克雷伯菌的耐药性变迁情况,为临床控制医院感染及合理用药提供依据。方法:回顾性分析2006-2010年医院使用法国生物梅里埃VITEK-32全自动细菌鉴定药敏仪及药敏试验卡从临床送检样本中分离鉴定出的大肠埃希菌和肺炎克雷伯菌对抗菌药物的耐药性变迁。结果:5年从临床各科送检样本中共分离出大肠埃希菌1722株和肺炎克雷伯菌872株,二者对常用抗菌药物耐药率呈持续高水平趋势,对阿米卡星、哌拉西林/他唑巴坦以及美罗培南的耐药率相对较低。结论:临床分离大肠埃希菌和肺炎克雷伯菌的耐药性十分严重,开展细菌耐药性监测对指导临床合理使用抗菌药物、防止医院感染意义重大。OBJECTIVE：To analyze the trend of drug resistance rate of Escherichia coli and Klebsiella pneumoniae in our hospital,for the guidance of nosocomial infection control and rational use of antibiotics.METHODS：E.coli and K.pneumoniae were isolated and tested by microbiological assay system of VITEK-32 and susceptibility test card from clinical samples.Drug resistance was analyzed and studied retrospectively.RESULTS：There were 1 722 strains of E.coli and 872 strains of K.pneumoniae isolated from our hospital in five years.E.coli and K.pneumoniae were resistant to common antibiotics at a high degree but susceptible to amikacin,tazobactam sodium/piperacillin sodium and meropenem.CONCLUSION：Drug resistance status of clinical isolated E.coli and K.pneumoniae to antibiotics is very serious.It is very important to monitor their drug resistance for the rational use of antibiotics and the prevention of nosocomial infection.

关 键 词：大肠埃希菌 肺炎克雷伯菌 耐药性 

分 类 号：R969.3[医药卫生—药理学] R378.2[医药卫生—药学]