壁虎提取物对U_(14)荷瘤鼠的药效研究  

Effect ofDifferent Extractive of Gecko on U_(14)-bearing Mice Model

作　　者：孙景存[1] 王永欣[1] 张洪亮[1] 王江静[1] 张生潭[1] 王春秀[1] 

机构地区：[1]河北省沧州中西医结合医院,河北沧州061000

出　　处：《四川中医》2012年第7期57-58,共2页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:研究壁虎不同方式提取物对U14荷瘤鼠的抗肿瘤作用。方法:制备小鼠U14肿瘤模型,观察壁虎全粉、壁虎水提物及壁虎水提醇沉物对U14荷瘤鼠的抑瘤效果。结果:生药量相等的壁虎全粉①组、壁虎水提物①组、壁虎醇沉物组肿瘤抑瘤率分别为24.27%、43.37%、48.41%;给药重量相等壁虎醇沉物组、壁虎水提物②组、壁虎全粉②组的肿瘤抑瘤率分别为48.41%、40.05%和6.23%,CTX组、壁虎水提物①组、壁虎醇沉物组与对照组比较差异极显著(P<0.01),其余各组抑瘤率比较无明显差异(P>0.05)。结论:壁虎水提醇沉物中对肿瘤有抑制作用的有效成分比较富集。Objective： To study the anti-cancer effect of different extractive of Gekko on U14-bearing mice model. Meth-ods： U14-bearing mice model was established to observe the anti-cancer effect of powder of Gecko, aqueous extract of Gecko, alcohol sediment of aqueous extract of Gecko. Results ： The tumor inhibition ratio of equal crud Gecko of powder of Gecko①, a- queous extract of Gecko①, alcohol sediment of aqueous extract of Gecko respectively were 24. 27% , 43. 37% , 48.41% ; the tumor inhibition ratio of equal weight of powder of Geeko②, aqueous extract of Geeko②, alcohol sediment of aqueous extract of Gecko respectively were 48.41%, 40. 05% , 6.23%. Concision： The anti-cancer active component of Gecko was enriched in alcohol sediment of aqueous extract of Gecko.

关 键 词：壁虎全粉 壁虎水提物 壁虎水提醇沉物 肿瘤 U14 

分 类 号：R249[医药卫生—中医临床基础]