重度烧伤病人体内锌铜变化及双盲法口服硫酸锌疗效观察  

Changes in body zinc and copper levels in severely burned patients and the effects of oral administration of ZnSO_4 by double blind method

作　　者：韩春茂[1] 丁岳梁 徐志刚[2] 许鼎荣 

机构地区：[1]浙江医科大学附属第二医院烧伤整形科 [2]浙江大学中心实验室

出　　处：《中华整形烧伤外科杂志》1990年第2期83-86,155,共4页

摘　　要：对二年内入院的46名重度烧伤病人采用双盲法服用硫酸锌660mg/日和安慰剂对照,发现治疗组血清锌回复至正常早于对照组,尿锌排出也相应多于对照组。两组基本愈合时间无显著差异。烧伤面积系数(Coefficient Unit of Burned Surface,UBS)大于180的重症病人治疗组较对照组提前8天愈合。愈合时治疗组血清锌高于正常对照组。提示重症烧伤病人服用锌剂有一定疗效,但疗程不宜过长。另外,还观察到两组病人血清铜基本上在正常范围内,但尿铜排出增加。The trace elements and the effect of zinc sulphate on wound healing of 46 severely burnedpatients in recent 2 years were studied. By double blind method 22 patients accepted capsularZnSO_4 (660mg) per day as treated group and 24 patients medical starch as control.ZnSO_4 andplacebo were taken from 3rd or 5th day post burn until healing. Serum and 24h urine Zn andCu were measured on days 3, 5, 9, 13 post burn and later weekly until healing. The changesof Zn and Cu in serum and urine in all patients were similar to the results reported byothers. But the serum Zn on day 9 and urine Zn. on days 5, 9, 13 post burn in treated groupwere significantly higher than that in control group. The basic wound healing time was samein both groups, but the patients in treated group whose coefficient UBS~* (Unit of BurnedSurface) was more than 180 were cured 8 days earlier than the patients of same severity incontrol group. At the healing the serum Zn in treated group was significantly higher thanthat in normal control group. while the serum Zn in control group was as same as in normalcontrol group.The rising to normal of value of Zn/Cu in treated group was significantly ear-lier than that in control group. But the linear regression equations of serum Zn and Cu, urineZn and Cu in both groups have no significant difference in the whole course of disease.No side effects of ZnSO_4 have been found during the course. Our result shows that it isnot necessary to supply oral ZnSO_4 routinely in general burn patients, but in lethal burn pa-tients to complement oral ZnSO_4 is helpful to improve early hypozincemia and promote woundhealing. It has been also suggested that the suitable course of oral administration of ZnSO_4is 4 to 6 weeks. Coefficient UBS=1 point per percentage of burn surface area + 3 points per percentage of deep burn surface area

关 键 词：锌 铜 创口愈合 烧伤 

分 类 号：R644.05[医药卫生—外科学]