基于PLS的虚热证大鼠模型表征评价体系的研究  

Study on the Valuation System for the Superficial Characteristics of the Rat Models with Heat-deficiency Syndrome Based on PLS

作　　者：韩冰冰[1] 王世军[1] 张发艳[1] 王媛[1] 张亚楠[1] 

机构地区：[1]山东中医药大学,山东济南250355

出　　处：《中医学报》2012年第8期971-973,共3页Acta Chinese Medicine

基　　金：国家重点基础研究发展计划(973计划)(编号:2007CB512601)

摘　　要：目的:探讨采用偏最小二乘回归(PLS)法对符合虚热证动物模型表征评价体系进行研究。方法:使用中药复方附子、干姜、肉桂建立虚热证大鼠模型,检测体温、一般状况、寒热趋向、自主活动及代谢能等表征,PLS法建立回归模型,并进行数据分析。结果:粪质地、粪色、平均趾温、体质量、肛温、单位体质量可代谢能、活动状态对模型有重要影响力(VIP>1)。结论:虚热证模型动物的主要症状及体征与虚热证的临床诊断基本相符,体现了虚热证阴虚内热的病理特点。Objective ：To discuss the valuation system for superficial characteristics of rat models with heat-deficiency syndrome in accordance with the theory of traditional Chinese medicine by PLS data analysis. Methods ： Rat models with heat-deficiency syndrome were established by compound preparation of Aconitum carmichaeli, Cinnamomi Cortex and Rhizoma Zingiberis. After the models were cop- ied, superficial characteristics such as body temperature, ordinary situation, cold and warm tendency, autonomy activities and metabolism energy were tested and the data were estimated by PLS. Results： Rat models of heat-deficiency syndrome were significantly influenced by stool texture and colors, average toe temperature, body weight, rectal temperature, metabolic energy to unit weight and activity state （ VIP 〉 1 ）. Conclusion ：The main symptoms and signs of animal models with heat-deficiency syndrome are consistent with the clinical diagnosis of heat-deficiency syndrome, which reflects the pathological features of ＂yin-deficiency and endogenous heat＂ of heat-deficiency syndrome.

关 键 词：PLS 虚热证 阴虚内热 模型评价 大鼠 

分 类 号：R285.5[医药卫生—中药学]