胃肠道系统功能评价技术体系的建立及其在中药配伍禁忌研究中的应用  

Establishment of Gastrointestinal Function Evaluation System and Its Application in Research on Incompatibility of Chinese Herbal Medicine

作　　者：华永庆[1] 段金廒[1] 钱大玮[1] 江曙[1] 丁爱华[1] 宿树兰[1] 郭建明[1] 

机构地区：[1]南京中医药大学/江苏省方剂高技术研究重点实验室,南京210046

出　　处：《世界科学技术-中医药现代化》2012年第3期1553-1561,共9页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家重点基础研究发展计划("973计划")项目(2011CB505300):基于"十八反"的中药配伍禁忌理论基础研究;负责人:段金廒;国家重点基础研究发展计划("973计划")项目(2011CB505303):"藻戟遂芫俱战草"配伍关系与毒效表征的基础研究;负责人:段金廒

摘　　要：胃肠道系统功能评价是中药配伍禁忌研究的重要内容。本文围绕胃肠运动、分泌、吸收、屏障功能及微生物菌群调节等方面,探索性构建了适宜于中药配伍禁忌研究特点的胃肠道系统功能评价技术体系;探讨中药反药组合通过促进或抑制胃肠运动与分泌功能,干预药物胃肠吸收过程,影响胃肠屏障功能,调节胃肠道菌群结构与生态诸环节,揭示其产生致毒增毒或减效降效及相互作用机制,以期为阐明中药配伍禁忌的科学内涵提供有效支撑。Evaluation of the gastrointestinal tract system function is a very important part for studying incompatibility of traditional Chinese medicine.This article focuses on gastrointestinal motility,secretion,absorption,barriers and microbiota,seeks to establish an evaluation system on gastrointestinal tract function which in accordance with the characteristics of Chinese herbal medicine incompatibility.And then,we discuss the possible mechanism of the incompatible herb combination interaction through the way of promoting or weakening gastrointestinal motility and secretion,affecting absorb process,influencing gastrointestinal barriers function,adjusting gastrointestinal environment and bacterial spectrum,with a view to provide support to research of Chinese herbal medicine incompatibility,seeks to establish a gastrointestinal function evaluation system which fitting to the character of Chinese herbal medicine incompatibility research.

关 键 词：中药配伍禁忌 胃肠道系统 功能评价 药物相互作用 

分 类 号：R289.1[医药卫生—方剂学]