医院深部真菌感染危险因素分析  

Risk factors for deep fungal infections in a hospital

作　　者：喻楠[1] 尚元元[1] 贾伟[2] 张云霞[2] 

机构地区：[1]宁夏医科大学总院皮肤性病科,宁夏银川750004 [2]宁夏医科大学总院检验科,宁夏银川750004

出　　处：《中华医院感染学杂志》2012年第13期2789-2791,共3页Chinese Journal of Nosocomiology

摘　　要：目的分析发生医院深部真菌感染的危险因素,为制定深部真菌感染防治策略提供依据。方法采用回顾性调查方法,收集2004-2008年在医院住院诊断为医院内深部真菌感染的261例患者临床资料,进行1∶1的病例对照研究,分析发生医院深部真菌感染的危险因素。结果患者年龄≥60岁、高血压、糖尿病、胃肠道手术、留置导尿、全胃肠外营养等16个因素是医院深部真菌感染的相关因素。结论医院深部真菌感染的主要危险因素为应用抗菌药物种类、全胃肠外营养、人工机械通气、年龄≥60岁,保护因素为经验性治疗,其相对危险度分别为4.779、3.712、1.724、1.070及0.025。OBJECTIVE To explore the risk factors for deep nosocomial fungal infections,so as to provide evidence for developing preventive strategies for the infections.METHODS By the means of retrospective survey,the clinical data of 261 patients diagnosed with deep fungal infections from 2004 to 2008 were collected.Case-control study was performed in a ratio of 1∶1;the risk factors for deep fungal infections were analyzed.RESULTS There were 16 related factors for deep fungal infections,including old age（≥60）,hypertension,diabetes mellitus,gastrointestinal tract operation,detaining urethral catheterization and total parenteral nutrition（TPN）,and so on.CONCLUSION The main risk factors for deep fungal infections in hospital are the type of antibiotics used,TPN,artificial mechanical ventilation,and old age（≥60）,empirical therapy is considered the protective factor,the relative risks are 4.779,3.712,1.724,1.070 and 0.025,respectively.

关 键 词：医院感染 真菌 危险因素 

分 类 号：R181.32[医药卫生—流行病学]