骨科ICU泛耐药细菌药敏试验及感染预防控制策略  

Drug susceptibility testing for pandrug-resistant bacteria in orthopaedic ICU and prevention and control strategies for infections

作　　者：贺兰霞[1] 季海生[2] 

机构地区：[1]临沂市人民医院骨科,山东临沂276003 [2]临沂市人民医院临床检验中心,山东临沂276003

出　　处：《中华医院感染学杂志》2012年第13期2928-2930,共3页Chinese Journal of Nosocomiology

摘　　要：目的探讨骨科ICU泛耐药鲍氏不动杆菌(EDRAB)和泛耐药铜假单胞菌(EDRPA)敏感药物及交叉感染的预防控制措施。方法收集2011年1-3月从骨科ICU患者分离的EDRAB及EDRPA各6株,分别利用随机扩增多态性DNA(DNA-RAPD)分型技术对患者分离株调查,采取相应的防控措施,对泛耐药菌用K-B法和仪器稀释法进行药物敏感试验确认。结果 EDRPA和EDRAB存在交叉感染,EDRPA和EDRAB对多黏菌素均敏感,EDRPA对米诺环素敏感;采取手卫生等控制交叉感染的预防控制策略后,无其他患者发生交叉感染。结论手卫生和环境清洁对控制泛耐药菌传播具有重要意义,对感染者及时采取有效的预防控制策略和联合有效抗菌药物,对控制泛耐药感染有着重要临床意义。OBJECTIVE To explore the drug susceptibility of extensively drug-resistant Acinetobacter baumannii（EDRAB） and extensively drug-resistant Pseudomonas aeruginosa（EDRPA） in orthopaedic ICU and the prevention and control measures for the infections.METHODS A total of 6 strains of EDRAB and 6 strains of EDRPA isolated from orthopaedic ICU from Jan to Mar I,2011 were collected,all the isolates were investigated by random amplified polymorphic DNA（RAPD） method,the corresponding preventive measures were adopted,the drug susceptibility testing for the pandrug-resistant isolates was performed by using K-B method and instrument dilution method.RESULTS There existed the cross infection of EDRPA and EDRAB,both EDRPA and EDRAB were sensitive to polymyxin,PDRBA was sensitive to minocycline,no cross infections occurred after implementing the prevention measures such as hand hygiene.CONCLUSION Hand hygiene and cleanness of the environment have great significance in the control of the spread of pandrug-resistant bacteria,and to take effective prevention strategies in combination with effective drugs will contribute to the control of pandrug-resistant bacteria infections.

关 键 词：泛耐药 医院感染 鲍氏不动杆菌 铜绿假单胞菌 

分 类 号：R378[医药卫生—病原生物学]