纳洛酮在心肺脑复苏中的临床应用研究  

Clinical study of naloxone during cardiopulmonary cerebral resuscitation

作　　者：陈少霖[1] 姚志军[1] 陈兴旺[1] 赖剑波[1] 周华锋[1] 

机构地区：[1]广州医学院附属深圳沙井医院,518104

出　　处：《山西医药杂志（上半月）》2012年第8期756-757,共2页Shanxi Medical Journal

基　　金：深圳市宝安区科技计划社会公益科研资助项目(2009360)

摘　　要：目的探讨纳洛酮在心肺脑复苏中的临床应用效果。方法随机选择60例心脏骤停患者,分为对照组和治疗组各30例。2组患者均立即采取常规心肺脑复苏,治疗组则加用纳洛酮辅助治疗,对比2组患者治疗后24h的血乳酸、β-内啡肽等指标及心肺脑复苏成功率。结果与对照组相比,治疗组治疗后的血乳酸、β-内啡肽均明显降低(P<0.05),治疗组脑复苏成功率显著高于对照组(P<0.01)。结论纳洛酮可提高心肺脑复苏的成功率,具备有效的辅助治疗作用。Objective To investigate the therapeutic effects of naloxone during cardiopulmonary cerebral resuscitation（CPCR）.Methods Sixty patients with cardiac arrest were divided into control group and observation group randomly.All patients were given routine CPCR method,and observation group were given naloxone additionally.Blood lactate,β-endorphin at 24 hours after CPRP and the success rate of CPCR in observation group were compared to those in the control group.Results Blood lactate,β-endorphin at 24 hours after CPRP were significantly decreased in observation group compared with control group（P〈0.05）.The success rate of CPCR in observation group were significantly higher than that in control group（P〈0.01）.Conclusion Naloxone can significantly increase the success of CPCR;it may become an effective assistant drug during CPCR

关 键 词：纳洛酮 心脏停搏 心肺复苏术 治疗结果 

分 类 号：R459.7[医药卫生—急诊医学]