水飞蓟宾在正常大鼠和肝损伤模型大鼠体内代谢的比较研究  

Comparing studies of silybin metabolism in normal rats and liver injury model rats

作　　者：刘洋[1] 张硕峰[1] 杨文宁[1] 欧阳国庆[1] 高晓燕[2] 赵保胜[2] 董红环[1] 张雷[1] 刘莉莹[1] 

机构地区：[1]北京中医药大学中药学院,100102 [2]北京中医药大学科研实验中心,100029

出　　处：《国际中医中药杂志》2012年第8期700-702,共3页International Journal of Traditional Chinese Medicine

基　　金：北京中医药大学自主选题项目（项目编号：2011JYB22JS-049）

摘　　要：目的研究水飞蓟宾在正常和肝损伤模型大鼠的体内分布与代谢差异。方法分别口饲正常组和免疫性肝损伤模型大鼠相同剂量的水飞蓟宾胶囊水溶液，HPLC法分别测定各类生物样品中不同时间的水飞蓟宾含量。结果正常组在各时间点各类生物样品中的水飞蓟宾含量均比模型组高，且正常组中水飞蓟宾在各脏器中分布的浓度由大到小顺序依次为肝脏〉肾脏〉血浆〉心脏，而模型组中为肾脏〉心脏〉肝脏〉血浆。结论水飞蓟宾在正常大鼠的分布与代谢与肝损伤模型大鼠有显著性差异。Objective To research the metabolism and distribution of silybin in normal rats and liver injury model rats. Methods The normal rats group and immunity liver injury rat models were fed with the same dose of silybin capsule, and HPLC was used to determine the silybin concentration in biological samples in different time. Results The silybin concentration in the normal group in biological samples was higher than the model group at different time. In the normal group, the consequence of silybin concentration in each viscera distribution from top to bottom was liver〉kidneys〉plasma〉heart, while in the model group the fact was kidneys〉heart〉liver〉plasma. Conclusion The difference of metabolism and distribution of silybin in normal rats and liver damage model rats was obvious.

关 键 词：水飞蓟宾 正常大鼠 模型大鼠 代谢 分布 

分 类 号：R285[医药卫生—中药学]