急性心肌梗死患者脑钠肽变化趋势与IABP球囊导管撤除时机关系的研究  

Relationship between changing trend of BNP and occasion of withdrawing IABP balloon catheter in patients with acute myocardial infarction

作　　者：肖军[1] 王洪叶[1] 许红玲[1] 王德水[1] 季春燕[1] 郭惠[1] 张伟[1] 杨庭树[2] 

机构地区：[1]解放军第309医院心内科,北京100091 [2]解放军总医院南楼心血管一科

出　　处：《中国循证心血管医学杂志》2012年第3期212-214,共3页Chinese Journal of Evidence-Based Cardiovascular Medicine

基　　金：北京市自然科学基金(7122178);军队临床高新技术重大项目资助(2010gxjs093)

摘　　要：目的探讨急性心肌梗死患者脑钠肽(BNP)变化趋势与主动脉内球囊反搏术(IABP)辅助治疗球囊导管撤除时机的关系。方法纳入89例急性心肌梗死并行IABP辅助治疗的患者,根据IABP球囊导管撤除时患者所处的血BNP变化趋势,将患者分为BNP上升段组(n=35)及BNP下降段组(n=54),比较两组患者病情好转率、病死率及住院时间。结果与BNP上升段组比较,BNP下降段组病情好转率高(92.6%vs.57.1%,P<0.01)、病死率低(3.7%vs.20%,P<0.01)、住院时间缩短[(14.5±5.7)dvs.(20.7±7.5)d,P<0.01]。结论 IABP辅助治疗急性心肌梗死,在血BNP处于下降阶段时撤除球囊导管临床治疗效果改善更明显。Objective To discuss the relationship between the change trend of brain natriuretic peptide （BNP） and occasion of withdrawing balloon catheter of intra-aortic balloon pumping （IABP） in patients with acute my- ocardial infarction （AMI）. Methods The patients with AMI （n = 89） treated with IABP were selected and divided, according to the change trend of serum BNP in the occasion of withdrawing balloon catheter,into BNP increasing group （ n = 35 ） and BNP decreasing group （ n = 54 ）. The improvement rate, mortality and time of hospital stay were com- pared between two groups. Results In BNP decreasing group, compared with BNP increasing group, the improvement rate was higher （92.6% vs. 57.1% ,P 〈0.01 ） ,mortality was lower （3.7% vs. 20% ,P 〈0.01 ） and time of hospital staywasshorter[（14.5±5.7） dvs. （20.7±7.5） d,P〈0.01]. Conclusion In the assistant treatment of AMI with IABP, the balloon catheter is withdrawn during the period of serum BNP decreasing and curative effect will be better.

关 键 词：脑钠肽 心肌梗死 主动脉内球囊反搏术 

分 类 号：R542.22[医药卫生—心血管疾病]