系统性红斑狼疮并发细菌及真菌感染的临床研究  

Clinical study on the patients with systemic lupus erythematosus complicated by infections

作　　者：李志军[1] 王翠兰 范晓云[1] 陈琳洁[1] 陶荣亚 

机构地区：[1]蚌埠医学院附属医院,233004

出　　处：《风湿病学杂志》2000年第3期165-168,共4页

摘　　要：目的　研究近年系统性红斑狼疮 (SLE)患者发生细菌与真菌感染的临床特点。方法　选择 1990年 1月至 1998年 5月确诊为SLE并发细菌和真菌感染的病例 96例 ,统计分析有关资料。结果　 96例SLE患者共发生 15 1例次感染 ,其中医院感染占 48 3% ;革兰氏阴性 (G-)杆菌和革兰氏阳性 (G+ )球菌感染分别占 40 4%和 30 5 % ,真菌占 18 5 % ,其他细菌占 10 6 % ;2 7例次(17 9% )感染由细胞壁缺陷型 (L型 )细菌引起。感染发生后 5 0 %以上的患者无明显感染中毒表现。结论　SLE患者感染的临床表现与一般感染有所不同 ;医院感染发生率较高 ;G-杆菌是其最常见病原菌。及时采集有关标本作L型细菌培养可减少对感染的误诊。Objective To investigate the clinical features of the patients with systemic lupus erythematosus (SLE) complicated by bacterial and/or fungal infection.Method Statistical analysis was carried out on the clinical and bacteriologic data of 96 patients with SLE complicated by bacterial and/or fungal infection.Results One hundred and fifty one episodes of infection occured in 96 patients with SLE,in which 48 3% were nosocomial infection.Gram negative bacilli,gram positive cocci,fungal and other bacterial infection accounted for 40 4%,30 5%,18 5% and 10 6%,respectively.In the bacterial infection,17 9% were caused by L form bacteria and more than 50% of the patients had no apparent toxic manifestations.Conclusion Patients with SLE tend to develop nosocomial infection with gram negative bacilli being the most common pathogens.The clinical manifestations of the infection are atypical.Careful inspection and monitoring,timely collecting the specimens for L form bacterial culture can reduce misdiagnosis and missed diagnosis of the infection.

关 键 词：系统性红斑狼疮 细菌感染 真菌病 并发症 

分 类 号：R593.24[医药卫生—内科学]