硫酸钙/富血小板血浆活性支架材料的制备  

Preparation of calcium sulfate and platelet-rich plasma bioactive scaffold

作　　者：张杨[1] 尚万兵[1] 

机构地区：[1]新乡医学院基础医学院,河南新乡453003

出　　处：《新乡医学院学报》2012年第8期585-586,共2页Journal of Xinxiang Medical University

摘　　要：目的探讨硫酸钙/富血小板血浆人工骨活性支架材料的制备。方法将富血小板血浆和硫酸钙混合后迅速搅拌至糊状,常温常压下压制成型,并用扫描电镜和X线衍射对复合物进行分析。结果硫酸钙晶体基本保持了原有的晶体形貌。复合支架材料以5～10μm硫酸钙柱状晶体为骨架,其间布满直径约1μm的片状晶体,分布均匀,使晶体间的结合更加紧密。硫酸钙支架材料产物为二水硫酸钙,主要出峰位置与二水硫酸钙基本一致,但强度有所变化,主峰附近小的衍射峰为血浆中的蛋白质成分形成。结论以硫酸钙/富血小板血浆制备的人工骨活性支架材料具骨诱导性,支架材料结构致密。Objective To explore the preparation of calcium sulfate and platelet-rich plasma bioactive scaffold. Meth- ods The calcium sulfate and platelet-rich plasma were mixed and then agitated quickly to pasty, and were molded. The com- pounds was analysed by scanning electron micrograph and X-ray crystal diffraction. Results Calcium sulfate crystals remained of the original crystal morphology. The columnar crystals of calcium sulfate （5 - l0 p^m） was the skeleton of composite scaffold. The composite scaffold was covered with flaky crystals which diameter of about 1 p^m. The flaky crystals were uniform distribu- tion, which made the crystals were more closely. Calcium sulfate scaffold was composed of calcium sulfate dehydrate, the main peak position was same with the calcium sulfate dehydrate ,but the intensity changed. The small diffraction peaks near the main peak were formed by protein of the plasma. Conclusion The artificial bioactive bone scaffolds which were prepared by calci- um sulfate/platelet-rich plasma have the bone induction, and the scaffold structure is dense.

关 键 词：硫酸钙 活性支架材料 富血小板血浆 

分 类 号：R318.08[医药卫生—生物医学工程]