锰对接触男工性腺激素水平的影响  

EFFECTS OF MANGANESE ON GONADAL HORMONE LEVEL IN MALE EXPOSED WORKERS

作　　者：姜岳明[1] 陆继培 谢佩意 吕志光[2] 黄锦利 张凤生 

机构地区：[1]广西医科大学公共卫生学院劳动卫生教研室,南宁530021 [2]八一铁合金职工医院,来宾5461022 [3]木圭锰矿职工医院,桂平537201

出　　处：《广西医科大学学报》2000年第1期20-22,共3页Journal of Guangxi Medical University

基　　金：广西教育厅资助项目!(9102 2)

摘　　要：目的 :评价接触锰对下丘脑 -垂体 -睾丸轴的影响 ,为保护工人生殖健康提供科学的参考依据。方法 :应用放射免疫法测定了 184名健康男工的血浆睾酮 (T)、血清促间质细胞激素 (L H)和促卵泡成熟激素 (FSH )含量 ,其中锰粉加工、冶炼、焊接和对照工人分别为 36 ,5 0 ,2 4和 74人。结果 ::冶炼作业环境空气中 Mn O2 浓度几何均值为 0 .17m g/ m3,工人血清 L H、 FSH含量高于对照组 (P <0 .0 5～ 0 .0 1) ,而血浆 T浓度正常。接锰工龄 5～ <10年的工人血清 FSH含量比对照组高 (P <0 .0 5 )。逐步回归分析显示血浆 T与空气锰浓度呈负相关 ,但分层分析未见显著性差异。结论 :锰对下丘脑 -垂体-睾丸轴的继发作用明显。Objective:The aim of this study was to evaluate the effect of manganese exposure on the hypothalamo pituitary testicular axis for protecting workers' reproductive health Methods:The concentrations of plasma testosterone (T),serum luteinising hormone (LH) and follicle stimulating hormone (FSH) were determined in 36 silling workers,50 smelters,24 welders and 74 control workers by radioimmuno assay Results:The geometric mean of MnO 2 concentration in the air of the smelting worksites was 0 17 mg/m 3,concentrations of serum LH and FSH were both significantly higher in the exposed smelters,but plasma T was not significantly different between the exposed and control workers Compared with control workers,those exposed for 5~<10 years had significantly raised FSH and normal LH and T concentrations The multiple regression analysis showed that the negative correlation was found between the plasma T and air manganese concentrations,but no significant differences were found among the exposed and control groups Conclusion:There is an obvious secondary effect of manganese on the hypothalamo pituitary testicular axis

关 键 词：锰 睾丸 促间质细胞激素 促卵泡成熟激素 职业病 

分 类 号：R135.1[医药卫生—劳动卫生] R698.2[医药卫生—公共卫生与预防医学]