吉法酯对DMF联合乙醇致大鼠急性胃黏膜损伤的预防保护作用  

Protective Effects of Gefarnate on Gastric Mucosal Lesions Induced by DMF and Alcohol in Rats

作　　者：郑学峰[1] 

机构地区：[1]辽宁医学院附属第一医院消化内科,辽宁锦州121001

出　　处：《医学与哲学（B）》2012年第7期56-58,共3页Medicine & Philosophy(B)

基　　金：辽宁省教育厅课题;项目编号:L2010296

摘　　要：研究吉法酯对DMF和乙醇联合致胃黏膜损伤的保护作用。大鼠随机分为3组。各组提前药物灌胃,然后用DMF和乙醇致胃损伤,测定胃黏膜溃疡指数、胃黏膜血流、胃黏膜氨基己糖含量,并观察组织学变化。预防组与损伤组比较,胃黏膜损伤指数明显下降,胃黏膜血流明显增加,胃黏膜氨基己糖含量亦明显增加。吉法酯对DMF和乙醇联合致大鼠急性胃黏膜损伤具有预防保护作用。To determine the protective effects of gefarnate on gastric mucosal lesions induced by Dimethylformamide （DMF） and alcohol in rats, 30 healthy male Wistar rats were randomly and equally divided into four groups： normal group, injury group, gefarnate protective group （400mg/kg）. Gastric mucosal lesions were induced by DMF and alcohol. Rats of protec- tive groups were pretreated with drugs that mentioned above respectively before induction of gastric mucosal lesions. Gas- tric mucosal blood flow and content of hexosamine were measured and the histological changes were evaluated under micro- scope. Compared with injury group, ulcer index of protective groups were significantly decreased （P〈0. 001}, gastric mu- cosal blood flow and content of hexosamine were significantly increased （P〈0. 001）. Inflammation and injury in histologi- cal slide of protective groups were slight. Gefarnate can reduce gastric mucosal lesions induced by DMF and alcohol in rats.

关 键 词：吉法酯 二甲基甲酰胺 乙醇 胃黏膜 预防保护 

分 类 号：R135[医药卫生—劳动卫生] R975[医药卫生—公共卫生与预防医学]