吲哚咔唑类化合物生物合成途径研究进展  

Progress advance in biosynthesis pathway of indolocarbazole

作　　者：董姣姣[1] 

机构地区：[1]青岛科技大学,山东青岛266042

出　　处：《天津化工》2012年第4期7-11,共5页Tianjin Chemical Industry

摘　　要：以雷别卡霉素和星形孢菌素为主要对象,陈述其合成过程中的基因、酶和中间产物。吲哚咔唑类化合物的生物合成主要分为吲哚环的形成、糖基的形成以及两者的连接。起始物色氨酸经过色氨酸修饰、双吲哚吡咯的形成和氧化环的闭合形成吲哚环,通过糖基转移酶将吲哚咔唑核心和糖基连接合成目标化合物。The biosynthesis of natural products staurosporine and rebeccamycin is summarized in this articl mainly concerning related genes, enzymes, and intermediates involved in the biosynthesis of indolocarbazole. The biosynthesis of indolocarbazole includes the formation of indolocarbazole ring, sugar moiety and the connection between the two parts. Originally, two modified tryptophan motifs undergo the formation of bisindole pyrrole and a decarboxylative ring closure to complete the formation of indolocarbazole ring. The resulting indolocarbazole core and the sugar moiety was linked by the glyeosyltransferase to synthesize the target compounds.

关 键 词：吲哚咔唑 雷别卡霉素 星形孢菌素 生物合成 生物碱 

分 类 号：TQ253.3[化学工程—有机化工]