MicroRNA在类风湿性关节炎中的研究进展  

Research Progress of MicroRNA in Rheumatoid Arthritis

作　　者：兰会华[1] 卢秋维[1] 覃桂芳[1] 

机构地区：[1]广西壮族自治区人民医院检验科,南宁530021

出　　处：《医学综述》2012年第14期2180-2183,共4页Medical Recapitulate

摘　　要：类风湿性关节炎(RA)是一种常见的累及多脏器损害的自身免疫性疾病,其病因未明及发病机制复杂。微小RNA(miRNA)是参与高等生物基因表达调控的重要分子,参与了RA的发病过程,有望成为新的诊断标志和治疗靶点应用于临床。随着人们对miRNA功能的深入研究,miRNA参与自身免疫性疾病及炎症性疾病不断被发现,在此主要综述miRNA在RA中的研究进展。Rheumatoid arthritis（RA） is a common autoimmune disease causing multiple organ damages. the pathogenesis of which is still unclear and complex. MieroRNA（miRNA） plays an important role in regulation of gene expression, which is involved in the pathogenesis of RA, and is expected to be a new diagnostic markers and therapeutic target in clinic. Along with the deeper research on miRNA functions, its involvement in autoimmune diseases and inflammatory diseases are discovered continuously, and here is to make a review focusing on the research orom＇ess of miRNA in RA.

关 键 词：MICRORNA 类风湿性关节炎 免疫系统 

分 类 号：R392.13[医药卫生—免疫学]