间歇低氧干预对实验性糖尿病大鼠病症的影响  

Effects of Intermittent Hypoxia on the Symptom in Experimental Diabetic Rats

作　　者：周燚[1] 李良鸣[2] 姚鑫[1] 石家瑾[1] 

机构地区：[1]贵州师范大学体育学院,贵州贵阳550001 [2]广州体育学院

出　　处：《现代预防医学》2012年第14期3620-3622,3626,共4页Modern Preventive Medicine

基　　金：贵州省科学技术厅;贵州师范大学联合科技基金资金资助项目(黔科合J字[2010]40号)

摘　　要：目的探索低氧干预对实验性糖尿病大鼠血糖及其病症的影响。方法采用长期高糖高脂膳食加小剂量链脲佐菌素(STZ)的方法建立糖尿病大鼠模型,将复制成功的模型大鼠随机分为模型对照组与低氧干预组。模型对照组在常氧环境下正常生活,低氧干预组大鼠每天在低氧帐篷内低氧暴露1 h(O2浓度15.4%±0.2%)、每周休息1 d、共干预4周。结果 (1)糖尿病大鼠出现了典型的"三多一少"特征。(2)通过4周实验干预,低氧干预组大鼠血糖稍高于模型对照组(P﹥0.05)、摄食量明显低于模型对照组(P﹤0.05)、体重下降显著大于模型对照组(P﹤0.05)、肥胖指数、饮水量、胰岛素敏感指数及胰岛素抵抗指数与模型对照组相比差异均无统计学意义(P﹥0.05)。结论持续4周每天1h低氧(O2浓度15.4%±0.2%)暴露对实验性糖尿病大鼠病症无明显改善作用,而体重下降更快、空腹血糖有升高趋势。OBJECTIVE To study the effect of hypoxia on the blood glucose and symptom in experimental diabetic rats.METHODS The model was established by long-term diet high sugar and fat food,lower dose（30mg/kg body weight）of the streptozocin（STZ）treated rats.They were randomly divided into model control group and hypoxia interfering group.Model control group lived under normal environment while hypoxia interfering group exposed to hypoxia for an hour per day in hypoxic tent（oxygen concentration 15.4% ± 0.2%）,six days a week for four weeks.RESULTS（1）The rats had the typical symptoms of diabetic.（2）Compared with the rats in Model control group,the ones in hypoxia interfering group had a non-significantly higher fasting blood glucose（FPG）（P﹥0.05）and a decreased food intake（P﹤0.05）as well as decreased weight（P﹤0.05）after four-week intervention period.But there was no significant difference in the drinking,the fat Index,the insulin sensibility index（ISI）and the insulin resistance index（HOMA-IR）between the two groups.CONCLUSION Four-week hypoxia interfering had no improvement to the diabetic symptoms in experimental diabetic rats apparently,in contrast it can result in a quick decrease in weight and an ascendant trend in FPG.

关 键 词：低氧 糖尿病 血糖 病症 

分 类 号：R587.1[医药卫生—内分泌]