临床感染的MRSA对万古霉素敏感性监测  

survey on the Susceptibility of clinical methicillin-resistant Staphylococcus aureus to vancomycin

作　　者：杜学娜 张岩[1] 董爱英[2] 张晓玲[1] 

机构地区：[1]河北港口集团有限公司秦皇岛港口医院检验科,河北秦皇岛066002 [2]河北联合大学附属医院检验科

出　　处：《现代预防医学》2012年第14期3634-3635,3638,共3页Modern Preventive Medicine

摘　　要：目的分析耐甲氧西林金黄色葡萄球菌(MRSA)在临床标本中的检出动态,监测MRSA对万古霉素药物敏感情况,防止出现万古霉素中介金黄色葡萄球菌(VISA)和万古霉素耐药金黄色葡萄球菌(VRSA)。方法检测并比较2006～2010年各年度临床标本中MRSA的检出率,用微量肉汤稀释法监测MRSA的万古霉素MIC值变化。结果金黄色葡萄球菌MRSA的检出率逐年升高,2010年与2006年比较,MRSA的检出率差异有统计学意义(P﹤0.05)。微量肉汤稀释法监测MRSA的万古霉素MIC值,5年间差异无统计学意义(P﹥0.05)。结论 MRSA检出率显著升高,应引起临床和实验室高度重视,秦皇岛地区医院未检出VISA和VRSA,但应密切关注其发展动向。OBJECTIVE To analyze the prevalence of methicillin-resistant Staphylococcus aureus（MRSA）,and monitor the susceptibility of MRSA to vancomycin so as to prevent the emergence of vancomycin-resistant S.aureus（VRSA）or vancomycin-intermediate S.aureus（VISA）.METHODS The incidence of MRSA isolated from all clinical samples from 2006 to 2010 was detected and compared.Broth dilution method was used to monitor the changes of MRSA in vancomycin MIC value.RESULTS MRSA detection rate has increased year by year.The incidence of MRSA in 2010 showed significant difference compared with that in 2006（P﹤0.05）.The MRSA in vancomycin MIC was detected by micro-broth dilution method,and there was no significant difference in the last five years.CONCLUSION The detection rate of MRSA increased significantly,which should be attached great importance to the clinical and laboratory.VISA or VRSA was not found in the strains,but we should pay attention to its development trend.

关 键 词：秦皇岛地区 耐甲氧西林金黄色葡萄球菌 耐药性 万古霉素 

分 类 号：R378.11[医药卫生—病原生物学]