双黄烧伤膏对大鼠烧伤、烫伤的治疗作用研究  

Experimental studies of shuanghuang burn ointment treatment for scald and burn wound of rat model

作　　者：朱晓红[1] 凌磊[1] 王杨[1] 王强[1] 

机构地区：[1]中国人民解放军第二○二医院药理基地,沈阳110003

出　　处：《实用药物与临床》2012年第7期385-387,共3页Practical Pharmacy and Clinical Remedies

基　　金：辽宁省自然科学基金资助项目(201102243)

摘　　要：目的研究双黄烧伤膏对大鼠实验性烫伤、烧伤感染的治疗作用。方法将大鼠随机分为实验组(双黄烧伤膏组)、阳性对照组(京万红软膏组)、空白对照组。建立大鼠Ⅱ度烫伤模型、Ⅲ度烧伤感染模型,分别涂布给药,单笼饲养,观察并记录创面变化。结果在大鼠烫伤实验中,给药15 d后,各组创面结痂面积明显变小,实验组结痂愈合时间短,与阳性对照组、空白对照组比较,差异有统计学意义(P<0.05、P<0.01);20 d创面面积与阳性对照组相比,差异无统计学意义(P>0.05),与空白对照组相比,差异有统计学意义(P<0.01)。在大鼠烧伤感染试验中,给药9 d后,实验组与阳性对照组相比,差异无统计学意义(P>0.05),与阴性对照组相比,差异有统计学意义(P<0.01)。结论双黄烧伤膏对大鼠实验性烫伤、烧伤感染具有较好的治疗作用。Objective To study the effects of shuanghuang bum ointment on scald and burned infectious rats. Methods Rats were randomly divided into test group （shuanghuang burn ointment）, positive control group （jingwan- hong cream）and no treatment group respectively. The drugs were administered topically on the surface of scalded and burned infection places respectively after partical-thickness scald and burn in rats. The change of the scalded and burned areas and the decrustation time were recorded. Results In the partical-thickness scalding test,the scalded areas of 15 d were smaller, there was significant difference between test group and positive control group （ P 〈 0.05 ）, there was sig- nificant difference between test group and no treatment group（ P 〈 0. 01 ） ; the scalded areas of 20 d： there was signifi- cant difference between test group and no treatment group（ P 〈0. 01 ） ,but there was no significant difference compared with the positive control group. In the partical-thickness burnning infection test, the scalded areas of 9 d, there was sig- nificant difference between the test group and the no treatment group（ P 〈 0.01 ） ,but there was no significant difference compared with the positive control group. Conclusion Burn ointment has a good anti-inflammatory, antibacterial and analgesic effect.

关 键 词：双黄烧伤膏 烫烧伤 感染 药效学 

分 类 号：R644[医药卫生—外科学]