注射用头孢替安与注射用氯诺昔康配伍稳定性考察  

Compatible stability of cefotiam hydrochloride for injection and lornoxicam for injection in 0.9% sodium chloride injection

作　　者：方宝霞[1] 苏翔[1] 陆连英[1] 朱军[1] 艾学勇[2] 

机构地区：[1]湖北医药学院附属东风医院药学部,湖北十堰442008 [2]湖北医药学院药学院,湖北十堰442000

出　　处：《实用药物与临床》2012年第7期417-419,共3页Practical Pharmacy and Clinical Remedies

摘　　要：目的考察注射用头孢替安与注射用氯诺昔康在0.9%氯化钠注射液中的配伍稳定性。方法在(25±1)℃下,采用HPLC法测定8 h内配伍液中头孢替安与氯诺昔康的含量变化,观察配伍液的外观,记录pH值。结果 8 h内,配伍液中氯诺昔康的含量无明显变化,头孢替安含量不断下降,8 h含量为80.8%,pH值随时间变化逐渐增大,溶液颜色随时间变化逐渐加深。结论注射用头孢替安与注射用氯诺昔康在0.9%氯化钠注射液中可配伍使用,但应在4 h内用完。Objective To study the compatibility stability ofcefotiam hydrochloride for injection and lornoxi- cam for injection in 0.9% sodium chloride injection. Methods The content of mixture solution of cefotiam hydrochlo- ride for injection and lornoxicam in 0. 9% sodium chloride injection was determined at room temperature （25 - 1 ）℃ within 8 h by HPLC,the appearance of the solution was observed,and the pH value was determined. Results No sig- nificant difference was found in content of lornoxicam in the mixture solution within 8 h, while the content of cefotiam hydrochloride decreased significantly,with 80. 8% of original content at 8 h. The pH value increased, and the colors deepened gradually. Conclusion The mixture of cefotiam hydrochloride with lornoxicarn in 0. 9% sodium chloride in- jection can be used at room temperature ,but it must be injected within 4 h .

关 键 词：头孢替安 氯诺昔康 高效液相色谱法 配伍 稳定性 

分 类 号：R942[医药卫生—药剂学]