肠道K细胞的研究进展  

Research progress of the intestinal K cells

作　　者：吕颖钺[1] 武晓泓[1] 

机构地区：[1]南京医科大学第一附属医院内分泌科,210029

出　　处：《国际内分泌代谢杂志》2012年第4期251-254,共4页International Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助项目（81070621/H0704）;江苏省医学重点人才项目（RC2011068）

摘　　要：K细胞作为一种肠道内分泌细胞，零散分布于胃肠道，从十二指肠至直肠递减，分泌葡萄糖依赖性促胰岛素多肽（GIP）。通过对STC-1细胞系及荧光标记K细胞的转基因小鼠的研究，三大营养物质调控GIP分泌的机制已逐步明了。肥胖状态存在K细胞数量及GIP含量的增加，而2型糖尿病则存在胰岛B细胞的GIP抵抗。减少K细胞增生或降低GIP分泌可能是一种新的减肥措施。利用患者自身K细胞，重新恢复内源性进餐刺激的胰岛素分泌，有望成为治疗糖尿病的潜在策略。As a kind of intestinal endocrine cells, K cells scatter in the gastrointestinal tract, decrea-sing from the duodenum to the rectum, and secreting glucose-dependent insulinotropic polypeptide （ GIP ）. Through the studies of STC-1 cell lines and fluoreseently labeled K cells of transgenic mice, the mechanism of the three major nutrients in the regulation of GIP secretion has gradually been revealed. The density of K cells and GIP content increase under obesity, and GIP resistance in islet β cell exists in type 2 diabetes. Preventing K cells hyperplasia or reducing GIP production may be a new therapeutic option to treat obesity. Utilizing a patient＇s own K cells to reestablish endogenous meal-regulated insulin secretion represents a potential strategy to treat diabetes.

关 键 词：K细胞 葡萄糖依赖性促胰岛素多肽 肥胖 糖尿病 

分 类 号：R587.1[医药卫生—内分泌]