高温复合烫伤对兔早期肝肾功能影响  

Impacts of hyperthemia and scald on hepatorenal function in rabbits

作　　者：孙俊锋[1] 刘上基[1] 詹剑华[1] 游浩元[1] 罗锦花[1] 

机构地区：[1]南昌大学第一附属医院烧伤科,江西南昌330006

出　　处：《中国公共卫生》2012年第8期1054-1056,共3页Chinese Journal of Public Health

基　　金：国家科技支撑计划(2008BA168B06)

摘　　要：目的观察高温复合烫伤对早期兔肝肾病理形态及主要生化指标改变。方法动物随机分为常温组、高温组、高温习服组,分别置于不同温度环境,烫伤,动态观察丙氨酸氨基转移酶(ALT)、肌酐(Cr)的变化及比较伤后48 h肝肾脏器病理形态改变。结果高温组有3只兔死亡,高温习服组有1只死亡,常温组无死亡;烫伤前,高温习服组兔血中ALT、Cr水平[(69.3±1.5)U/L、(72.0±6.5)μmol/L]明显高于常温组[(43.3±4.5)U/L、(61.0±3.6)μmol/L)]和高温组[(46.3±7.6)U/L、(61.3±3.6)μmol/L)](P<0.05);烫伤后,高温习服组和高温组ALT、Cr各时相点均明显高于常温组,而伤后48 h高温习服组ALT、Cr值[(136.0±7.0)U/L、(211.5±7.2)μmol/L]明显低于高温组[(167.0±24.9)U/L、(211.5±7.2)μmol/L](P<0.05);高温组兔肝、肾组织损伤程度较其他2组严重。结论高温及烫伤复合应激对机体有损害作用,高温习服有利于减轻这种复合应激对脏器功能的损伤。Objective To observe early changes of hepatorenal function and the changes of visceral pathology after hyperthermia and scald in rabbits.Methods The rabbits were randomly divided into normal environment group,hyperthermia group,and heat acclimatization group and reared in the environment with different temperature and exposed to scald.Alanine aminotransferase（ALT）,creatinine（Cr） were dynamically detected and pathomorphologic changes of liver and kidney 2 days after scald exposure were compared for the rabbits.Results There was no death in normal environment group;one rabbit dead in heat acclimatization group and 3 rabbits dead in hyperthermia group.ALT（69.3±1.5 U/L） and Cr（72.0±6.5 umol/L） of the rabbits in heat acclimatization group were obviously higher than those of normal environment group（43.3±4.5 U/L and 61.0±3.6 umol/L） and hyperthermia group（46.3±7.6 U/L and 61.3±3.6 umol/L;P〈0.05）.ALT,Cr of the rabbits in hyperthermia group and heat acclimatization group were obviously higher than those of normal environment group after burn.ALT（167.0±24.9 U/L） and Cr（211.5±7.2 μmol/L） of the rabbits in hyperthermia group were obviously higher than those of heat acclimatization group（136.0±7.0 U/L and 155.3±2.2 μmol/L;P〈0.05） after burn exposure.The liver and kidney were injured most seriously in hyperthermia group.ConclusionThe combined effects of hyperthermia and burn are far stronger than burn and heat acclimatization might be beneficial to relieve the combined effects in scalded rabbits under hyperthermia environment.

关 键 词：高温 高温习服 脏器功能 生化指标 病理形态 烧伤 

分 类 号：R644[医药卫生—外科学]