维拉帕米治疗高血压患者舒张功能不全的临床研究  

Verapamil in Treatment of Diastolic Dysfunction in Patients with Hypertension

作　　者：颜彦[1] 朱伟[2] 程蕾蕾 王齐冰[1] 林佑善[1] 

机构地区：[1]上海医科大学中山医院心内科,200032 [2]上海医科大学中山医院心脏超声室,200032

出　　处：《中国临床医学杂志》2000年第1期69-70,共2页

摘　　要：目的：研究维拉帕米治疗高血压患者左心舒张功能不全的作用。方法：对２４例高血压患者，应用心动超声（心超）多普勒测定二尖瓣水平舒张早期血流速度曲线峰值（Ｅ）与心房收缩期血流速度曲线峰值（Ａ）及左室射血分数（ＬＶＥＦ），结果：服药５周后心率（ＨＲ）及舒张压（ＤＢＰ）、Ａ值均减低（分别为６９．１８±６．５２与７６．２３±８．７２次／分，８２．６１±８．９５与９８．４４±１０．３４ｍｍＨｇ，６６．３０ ± １４．０４与７３．９４ ± １２．２８ ｃｍ／ｓ，Ｐ均＜０．００１），Ｅ与Ｅ／Ａ值增加（分别７１．４９±９．８４与５２．２２±１１．８９ ｃｍ／ｓ，１．０９１±０．２６与０．７２７±０．１７，Ｐ均＜０．００１）。结论：维拉帕米可显著改善高血压患者的左心舒张功能不全。Objective: To investigate the effect of verapamil in treatment of diastolic dysfunction in patients with hypertension. Methods: The peak early diastolic mitral flow velocity (E) and the peak late mitral flow velocity during atrial constraction (A) and the left ventricular ejective fraction (LVEF) were measured by Doppler echocardiography in hypertensive patients. The patients in whom E/Aratio< 1 and LVEF>45 % were included in the study. The verapamil sustained - release tablets were administered for 5 weeks. The rest heart rate (RR) blood pressure (BP ) .E velocity.A velocity and E/A ratio were detected before and after 5 weeks therapy with the sustained - release verapamil. Results: There are twenty - four patients in the study, the RR.DBP(diastolic blood pressure) and A velocity were decreased after 5 weeks therapy (69. 18 ± 6. 52 Vs 76. 23 ± 8. 72 (BPM), 82. 61 ± 8. 95 Vs 98. 44 ± 10. 34(mmHg), 66. 30 ± 14. 04 Vs 73. 94 ± 12. 28(cm/s), all P < 0.001), E and E/A were increased (71. 49 ± 9. 84 Vs 52. 22 ± 11. 89 (cm/s), 1. 091 ± 0. 26 Vs 0. 727 ± 0. 17, both P < 0.001). Aspnea was relieved after therapy in patients who have the symptom before therapy. Conclusion: Verapmil can improve diastolic dysfunction in patients with hypertension significantly.

关 键 词：维拉帕米 高血压 舒张功能不全 药物疗法 

分 类 号：R544.106[医药卫生—心血管疾病] R541.905[医药卫生—内科学]