阻塞性睡眠呼吸暂停低通气综合征患者日间嗜睡与P物质水平的关系  

Relationship between serum substance P levels and excessive daytime sleepiness in patients withobstructive sleep apnea-hypopnea syndrome

作　　者：庄锡彬[1] 黄鸿波[1] 陈伟文[1] 黄弘[1] 郭伟峰[1] 

机构地区：[1]福建医科大学附属泉州市第一医院呼吸内科,362000

出　　处：《中华结核和呼吸杂志》2012年第8期606-609,共4页Chinese Journal of Tuberculosis and Respiratory Diseases

摘　　要：目的探讨P物质水平与OSAHS患者日间嗜睡的关系。方法纳入2009年1月至2010年12月福建医科大学附属泉州市第一医院呼吸内科因鼾症就诊的患者120例，根据多导睡眠监测结果分为单纯鼾症组及OSAHS组：单纯鼾症组30例，男24例，女6例，平均年龄为（48±15）岁，平均AHI为（2．8±1．6）次／h；OSAHS组90例，其中男78例，女12例，平均年龄为（49±12）岁，平均AHI为（37．1±23．7）次／h。采用Epworth嗜睡量表（Epworth sleepiness scale，ESS）进行嗜睡程度评估，放射免疫法测定血浆P物质水平。结果2组患者在性别、年龄及体重指数等方面均匹配。OSAHS患者ESS评分为（13±5）分，高于单纯鼾症患者（F=10．299，P〈0．05），且OSAHS病情较重，其评分也较高。OSAHS患者P物质水平为（132±27）ng／L，低于单纯鼾症患者（F=3．048，P〈0．05），且OSAHS病情越重P物质水平越低。相关性分析显示OSAHS患者P物质水平与ESS评分呈负相关（r=-0．238，P〈0．05）。结论OSAHS患者日问嗜睡程度升高，P物质水平降低，二者存在一定的相关性。Objective To investigate the relationship between serum Substance P levels and excessive daytime sleepiness （EDS） in patients with obstructive sleep apnea-hypopnea syndrome（OSAHS）. Methods A total of 120 adult habitual snorers treated by respiratory physicians in First Hospital of Quanzhou Affiliated to Fujian Medical University were selected for this study. The patients were grouped as simple snorers and OSAHS by the results of polysomnography test. Thirty patients were in the simple snorer group, among whom 24 were male and 6 were female. Their average age was （48 ± 15） years and average AHI was （2. 8 ±1.6） events/hour. Ninety patients were in the OSAHS group, among whom 78 were male and 12 were female. Their average age was （49±12 ） years and average AHI was （37. 1 ± 23.7 ） events/ hour. EDS was assessed using the Epworth sleepiness scale （ESS）. Substance P levels were analyzed with a radioimmunoassay. Results There was no significant difference in gender, age, and body mass index between the 2 groups. The ESS score for patients with OSAHS was （ 13 ±5）, higher than that for patients in the simple snorer group （ F = 10. 299, P 〈 0. 05 ）. With increasing severity of OSAHS, the score increased. The serum Substance P level for OSAHS group was （132± 27） ng/L, which was lower than that in the control （F = 3. 048, P = 0. 031 ）, and decrease in Substance P level was most significant in patients with severe OSAHS. Pearson correlation analysis showed that Substance P levels in OSAHS patients were negatively correlated with ESS scores （ r = - 0. 238, P 〈 0. 05 ）. Conclusions Substance P levels were lower in OSAHS patients with higher degree of daytime sleepiness. Daytime sleepiness and Substance P level were interrelated in patients with OSAHS.

关 键 词：睡眠呼吸暂停低通气综合征 日间嗜睡 P物质 

分 类 号：R766[医药卫生—耳鼻咽喉科]