气相色谱-质谱联用法测定沙纳唑的血药浓度  

Determination of Sanazole in Plasma on Lung Cancer Patients by GC/MS

作　　者：舒融[1] 骆传环[1] 鲍云华[2] 

机构地区：[1]军事医学科学院放射医学研究所,北京100850 [2]军事医学科学院附属医院,北京100039

出　　处：《质谱学报》2000年第1期14-17,共4页Journal of Chinese Mass Spectrometry Society

基　　金："国家九五重点科技攻关项目"资助 ;编号 :96-90 2 -0 1 -0 5

摘　　要：用气相色谱 -质谱联用法 ,选用甲硝唑为内标物 ,测定了肿瘤病人给药后血浆中沙纳唑的浓度 ,方法简便、准确。Sanazole is an radiosensitizer for cancer radiotherapy.We determined its concentration in plasma on lung cancer patients using GC/MS.Complete chroma tographic resolution was achieved using a HP OV 1 fused silica capillary column and the internal standard was metronidazole.The result showed that the elimination of sanazole was quick,which suggested the drug does not easily remain in body.

关 键 词：沙纳唑 血药浓度 肿瘤放疗增敏剂 GC-MS 

分 类 号：R979.19[医药卫生—药品] R446.11[医药卫生—药学]