铁调素的表达与调节机制研究进展  

Research Advances of Hepcidin Expression and Its Regulation Mechanism——Review

作　　者：常春康[1] 张曦[1] 肖超[1] 顾树程[1] 李晓[1] 

机构地区：[1]上海市交通大学附属第六人民医院血液科,上海200233

出　　处：《中国实验血液学杂志》2012年第4期1030-1033,共4页Journal of Experimental Hematology

基　　金：国家自然科学基金(编号81170463);上海市科委白玉兰基金(编号2010B089);交大医工交叉项目(编号YG2010MS42)

摘　　要：铁调素调节细胞铁的外向转运,其表达受机体信号因子(如血清铁和促红细胞生成素水平)以及炎症、低氧等疾病状态的影响。这些刺激通过肝实质细胞表面的组织相容性Ⅰ型跨膜糖蛋白HFE,转铁蛋白受体1和2,铁调素调节蛋白激活BMP-SMAD、JAK-STAT和HIF1等信号通路,改变铁调素基因的转录,调节铁调素的表达水平。但目前对调节铁调素表达的分子机制还不明确。本文从影响铁调素表达的信号因子及参与其表达调控的信号通路两方面入手,对铁调素表达的调节机制方面的最新研究进展加以综述。Hepcidin can regulate cell irons＇effiux transport. The expression of hepcidin can be influenced by the body signals （such as serum ferritin and erythropoietin levels ） as well as inflammation, hypoxia and other disease states. These stimulus activate the signaling pathway of BMP-the SMAD, the JAK-STAT and HIF1 through the liver parenchymal cell surface type Ⅰ transmembrane glycoprotein of HFE, transferrin receptor 1, 2, hepcidin regulatory proteins, thereby changing the hepcidin gene transcription, regulating the expression levels of hepcidin. However, the molecular mechanism that regulate hepcidin expression is unclear. From the signal factors that affect hepcidin expression and signaling pathways involved in its expression, the latest research progress on regulatory mechanism of hepcidin are summarized.

关 键 词：铁调素 铁调素调节蛋白 BMP/SMAD JAK—STAT HIF1信号通路 

分 类 号：R589.9[医药卫生—内分泌] R596[医药卫生—内科学]