尾吊大鼠血液细胞电阻抗谱的Cole-Cole模型分析  

Analysis of Electrical Impedance Spectroscopy of Blood Cells in Tail-Suspension Rats with Cole-Cole Models

作　　者：宫宇[1] 马青[1] 陈林[1] 沈斌[1] 方云[1] 

机构地区：[1]浙江省宁波大学医学院,浙江宁波315211

出　　处：《航天医学与医学工程》2012年第4期243-246,共4页Space Medicine & Medical Engineering

基　　金：宁波市自然科学基金项目(2010A610074)

摘　　要：目的利用Cole-Cole数学模型研究尾吊大鼠血液细胞电阻抗频谱的变化。方法通过非线性数值计算,对血液细胞的Bode图,Nyquist图和Nichols图进行Cole-Cole方程的曲线拟合,比较对照组(Con)与尾吊组(SUS)Cole-Cole模型参数。结果尾吊60 d大鼠血液细胞电阻抗频谱Cole-Cole模型参数变化显示:阻抗高频极限值(R∞)和阻抗增量(ΔR1,ΔR2)减小;特征频率(fC1,fC2)和β驰豫散射角(α1,α2)增加。结论可以通过Cole-Cole数学方程参数表达尾吊大鼠血液细胞电阻抗频谱特性变化。Objective To study the changes of electrical impedance spectrum （EIS） of blood in tail-suspended rats by using the Cole-Cole mathematical model. Methods The difference in the Cole-Cole model parameters of blood cells were compared between the control group （Con） and the tail suspension group （SUS） with the curve fitting in the Bode diagram, the Nyquist diagram and Nichols diagram by non-linear numerical calcula- tion of the Cole-Cole equation. Results The changes of Cole-Cole model parameters in rats＇ blood after 60 d tail-suspension were as follows： High-frequency limit of impedance （R∞） and the impedance increment （ΔR1,ΔR2） decreased; the characteristic frequency （α1,α2） and the fl dispersion angle （α1,α2） in- creased. Conclusion The changes of electrical impedance spectral characteristics of blood cells in tail suspen- ded rats can be expressed by the parameters of the Cole-Cole mathematical equation.

关 键 词：尾吊 血液细胞 阻抗频谱 Cole-Cole数学模型 

分 类 号：R857.3[医药卫生—航空、航天与航海医学]