改进的Perkin法催化合成香豆素  

Catalytic Synthesis of Coumarin by Modified Perkin Method

作　　者：肖如亭[1] 李乃 董庆洁[1] 吴志东[1] 葛明 

机构地区：[1]天津理工学院化工系,天津300191

出　　处：《应用化学》2000年第3期288-291,共4页Chinese Journal of Applied Chemistry

基　　金：天津市教育委员会高等学校科研基金! (96 2 0 3B)

摘　　要：对以水杨醛和乙酸酐为原料合成香豆素的工艺进行了改进 .采用乙酸钙为催化剂、PEG为活化剂的工艺路线 .用 HPL C跟踪反应过程 ,对催化剂和活化剂的用量、乙酸酐的用量和用法及保温反应的温度和时间对香豆素收率的影响进行了研究 .水杨醛与乙酸酐的总摩尔比为 1∶1.9,反应近终点时在 ( 2 14± 2 )℃保温反应 0 .5h,香豆素收率达 86.6% .The Perkin method for coumarin synthesis from salicylaldehyde and acetic anhydride has been improved by using calcium acetate as catalyst and polyethylene glycol as activator. The influences of the catalyst, activator, acetic anhydride and thermostatic reaction temperature and time on the yield of coumarin were studied. The yield of coumarin could be reached up to 86.6% with lower consumption of acetic anhydride in case the total molar ratio of acetic anhydride to salicylaldehyde=1 9∶1 and the reaction was kept 0.5 h at 212~216 ℃ when the reaction was close to the end.

关 键 词：香豆素 Perkin方法 乙酸钙 合成 催化剂 乙酸酐 

分 类 号：O626.31[理学—有机化学] O621.36[理学—化学]