食物不耐受与儿童慢性腹痛的相关性研究  

Correlation between Food Intolerance and Chronic Abdominal Pain in Children

作　　者：李玉华[1,2] 项立[1,2] 肖智辉[1,2] 王慧慧[1,2] 

机构地区：[1]暨南大学附属第二临床医学院 [2]深圳市人民医院儿科,广东省深圳市518020

出　　处：《中国全科医学》2012年第19期2170-2172,共3页Chinese General Practice

摘　　要：目的探讨食物不耐受与儿童慢性腹痛的相关性及不耐受食物忌食或轮替疗法对慢性腹痛患儿的疗效。方法采用酶联免疫吸附试验(ELISA)法检测68例以腹痛>3个月为主诉就诊的门诊患儿血清14种食物特异性免疫球蛋白(IgG)水平,同时进行3个月不耐受食物忌食或轮替疗法,观察疗效。结果慢性腹痛患儿食物不耐受阳性率为98.5%,牛奶、鸡蛋的阳性率最高,其次为鳕鱼、西红柿、大豆、螃蟹等。女性患儿鳕鱼、西红柿不耐受程度高于男性(Z值分别为2.096和2.038,P值分别为0.036和0.042)。≤6岁组与>6岁组患儿鸡蛋、西红柿、大豆IgG水平比较差异均有统计学意义(Z值分别为3.326、2.100和2.934,P值分别为0.001、0.036和0.003),年龄越大,鸡蛋、大豆不耐受程度越轻,西红柿不耐受程度越重。不耐受食物忌食或轮替疗法有效率为92.6%。结论儿童慢性腹痛与食物不耐受关系密切。不耐受食物以牛奶、鸡蛋最多见。不耐受食物忌食或轮替疗法对大多数慢性腹痛患儿有效。Objective To investigate the correlation between food intolerance and chronic abdominal pain in children and to discuss the efficacy of restraint of intolerant food or alternative therapy on children with chronic abdominal pain.Methods The enzyme-linked immunosorbent assay（ELISA） was used to measure the levels of IgG against 14 common foods in serum of 68 children with chronic abdominal pain more than three months.The efficacy of restraint of intolerant food or alternative therapy was observed after three months.Results Total positive rate of food intolerance in chronic abdominal pain children was 98.5%,with milk and egg having the highest positive rate,followed by cod,tomato,soybean and crab.The intolerance level of cod and tomato were higher among girls than among boys（Z=2.096,2.038,P=0.036,0.042）.The IgG level of egg,tomato and soybean showed statistically significant difference between children≤6 years and〉years group（Z=3.326,2.100,2.934,P=0.001,0.036,0.003）.And the more the age of children was,the lower the intolerance of egg and soybean was,and the higher the intolerance of tomato was.The efficacy of restraint of intolerant food or alternative therapy was 92.6%.Conclusion Chronic abdominal pain in children is closely related to food intolerance.Milk and egg are the most common intolerant food.The restraint of intolerant food or alternative therapy shows satisfactory efficacy in the treatment of most children with chronic abdominal pain.

关 键 词：食物不耐受 儿童 腹痛 

分 类 号：R725.72[医药卫生—儿科]