2型糖尿病患者24小时尿8-异前列腺素F2a及血清胱抑素C与肾脏损害的关系研究  

Relationship between 24-hour Urinary 8-iso-PGF2a,Cystatin C and Renal Damage in Patients with Type 2 Diabetes Mellitus

作　　者：邱宇珍[1] 刘志平[1] 杨杨[1] 

机构地区：[1]武汉科技大学附属天佑医院内分泌科,湖北省武汉市430064

出　　处：《中国全科医学》2012年第20期2298-2299,2303,共3页Chinese General Practice

摘　　要：目的探讨2型糖尿病患者体内氧化应激、胱抑素C(Cys C)水平变化特点及与肾脏损害的相关性。方法选取120例2型糖尿病患者,按照24 h尿微量清蛋白定量将患者分为A组(尿微量清蛋白<30 mg/24 h,60例)和B组(尿微量清蛋白30～299 mg/24 h,60例);另选取40例健康体检者作为对照组(C组)。比较3组受检者的体质指数(BMI)、空腹血糖(FPG)、糖化血红蛋白(HbA1c)、血清Cys C(Cys C)、24 h尿8-异前列腺素F2a/肌酐(8-iso-PGF2a/Cr)。结果 A组、B组患者血清Cys C水平及24 h尿8-iso-PGF2a/Cr均显著高于C组(P<0.01),且B组又显著高于A组(P<0.01)。多元逐步回归分析显示,24 h尿8-iso-PGF2a/Cr与血清Cys C水平呈正相关(r=0.674,P<0.01)。结论 Cys C、24 h尿8-iso-PGF2a/Cr均在糖尿病患者中明显升高,其升高程度与肾脏损害程度一致。Objective To study the relationship between 24-hour urinary 8-iso-PGF2a,serum Cystatin C（Cys C） and renal damage in patients with type 2 diabetes mellitus.Methods 120 patients with type 2 diabetes mellitus were divided into group A（microalbuminuria〈30 mg/24 h,60 cases） and group B（30 mg/24 h≤microalbuminuria≤299 mg/24 h,60 cases） according to the level of 24-hour microalbuminuria.40 healthy physical examiners were involved as control group（group C）.BMI,FPG,HbA1c,Cys C and the value of 8-iso-PGF2a/Cr were compared in the three groups.Results The levels of Cys C and the value of 24-hour urine 8-iso-PGF2a/Cr in group A and group B were significantly higher than those of group C（P〈0.01）,and those of group B were also significantly higher than those of group A（P〈0.01）.Multiple stepwise regressions showed that 24-hour urine 8-iso-PGF2a/Cr was positively correlated with the level of serum Cys（r=0.674,P〈0.01）.Conclusion The level of serum Cys C and 24-hour urine 8-iso-PGF2a/Cr both increase in patients with type 2 diabetes mellitus and the increasing level is correlated with the severity of nephropathy.

关 键 词：糖尿病肾病 胱抑素C 氧化性应激 8-异前列腺素F2A 

分 类 号：R587.1[医药卫生—内分泌]