分子烙印手性固定相分离过程热力学研究  

Thermodynamic Study on Separation of Molecular Imprinting Chiral Stationary Phase

作　　者：王进防[1] 周良模[1] 刘学良[1] 王清海[1] 朱道乾[1] 

机构地区：[1]中国科学院大连化学物理研究所,大连116012

出　　处：《高等学校化学学报》2000年第6期930-933,共4页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金! (批准号 :2 95 75 2 12 )

摘　　要：考察了温度对分子烙印固定相手性分离的影响 ,计算了手性分离过程中的热力学参数 .结果表明 ,分子烙印手性固定相的分离过程为焓控制过程 .随着温度的升高 ,样品的容量因子降低 ,手性选择因子 α减小 .样品与分子烙印固定相的作用力包括非特异作用力和特异作用力 ,只有特异作用力的差值才是手性分离的本质 .分子烙印产生的空穴对热力学参数有较大的影响 ,烙印分子与烙印空穴的匹配性最好 ,烙印空穴对烙印分子的结合在能量和构型上都是有利的 .The effect of temperature on the chiral separation of the molecular imprinting polymer was investigated and the thermodynamic parameters were calculated. It was found that the chiral separation process was enthalpy controlled. Increasing the temperature decreases the capacity factor and chiral selectivity factor. The interactions between the analyte and the molecular imprinting chiral stationary phase were both non specific and specific, and only the difference of specific interaction results in the chiral separation. The imprinting cavities affected the thermodynamic parameters dramatically. The rebinding of the imprinted molecule into the imprinting cavities was favorable in view of energy and configuration because of their best compatibleness. [WT5HZ]

关 键 词：分子烙印聚合物 手性固定相 手性拆分 HPLC 

分 类 号：O657.72[理学—分析化学] O641.6[理学—化学]