结核性胸腔积液患者血清及胸腔积液中脯氨肽酶活性分析  

Prolidase activity in serum and pleural fluids in patients with tuberculous pleural effusion

作　　者：胡振红[1] 吴妍雯[1] 傅祖红[1] 文芸[1] 刁波[2] 周芳[2] 

机构地区：[1]广州军区武汉总医院呼吸内科,湖北武汉430070 [2]广州军区武汉总医院医学实验科,湖北武汉430070

出　　处：《临床肺科杂志》2012年第9期1667-1668,1722,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的了解结核性与非结核性胸腔积液患者的血清及胸腔积液中脯氨肽酶(PLD)活性的差异,分析PLD对结核性胸腔积液的诊断意义。方法用ELISA法测定26例结核性胸腔积液患者(观察组)和28例非结核性胸腔积液患者(对照组)血清及胸腔积液中PLD水平,应用t检验统计分析结果。结果观察组血清及胸腔积液PLD活性水平高于对照组(P<0.05)。结论 PLD活性检测对鉴别结核性胸膜炎和其他疾病所致胸腔积液有重要意义。Objectives In this study we aimed to evaluate pleural fluid and serum prolidase（PLD） activities in patients with tuberculous（TB） pleurisy and compared with those in non-tuberculous（non-TB） pleural effusions.Methods PLD activity in pleural fluid-and serum sample collected from 26 patients with tuberculous（TB） pleurisy and 28 patients with non-tuberculous（non-TB） pleural were measured using ELISA method.ResultsProlidase enzyme activities in serum and pleural fluids of TB groupwere significantly higher than those values in non-TB group.Prolidase activities in pleural fluid were significantly higher than those in serum in both groups.There was a significant positive correlation between pleural and serum prolidase activities in TB group and in non-TB group.ConclusionIn conclusion,there is an elevated pleural fluid and serum prolidase enzyme activity in patients with TB pleurisy compared with non-TB pleurisy group.The higher enzyme activities in TB group might reflect increased collagen turnover in those patients.

关 键 词：脯氨肽酶 结核 胸腔积液 

分 类 号：R521.7[医药卫生—内科学]