短期胰岛素强化治疗对2型糖尿病微量清蛋白尿的影响  

Influence of short-term intensive insulin therapy on microalbuminuria in the patients with type 2 siabetes mellitus

作　　者：王炜[1,2] 叶山东[1,2] 李素梅[1,2] 陈超[1,2] 邢学农[1,2] 任安[1,2] 王菊梅[1,2] 

机构地区：[1]安徽医科大学附属安徽省立医院内分泌科 [2]安徽省立医院糖尿病研究室,合肥230001

出　　处：《安徽医学》2012年第7期821-823,共3页Anhui Medical Journal

摘　　要：目的研究短期胰岛素强化治疗对2型糖尿病(T2DM)微量清蛋白尿的影响。方法选取118例伴微量清蛋白尿的2型糖尿病患者,分别予以短期胰岛素强化治疗和口服降糖药治疗,对比治疗前后尿清蛋白肌酐比(ACR)、空腹血糖(FPG)、早餐后2 h血糖(2hPG)以及血压的变化。结果通过短期胰岛素强化治疗,患者的血糖和尿ACR明显下降(P<0.01),而血压性差异无统计学意义(P>0.05)。结论短期胰岛素强化治疗来控制血糖有助于减少尿蛋白。Objective To observe the influence of short -term intensive insulin therapy on the microalbuminuria in patients with type 2 diabetes mellitus （T2DM）. Methods In this study, we recruited 118 patients diagnosed type 2 diabetes mellitus with mieroalbumin- uria to be treated with either multiple insulin injections daily or oral antidlabetie drugs. The urinary albumin to creatinine ratio （ACR） , fast- ing plasma glucose （FPG） , 2 -hour plasma glucose （2hPG） and blood pressure （BP） were recorded before and after the intensive insulin therapy, respectively. These data were analyzed by t - test. Results The urinary ACR and blood glucose in type 2 diabetic patients signifi- cantly decreased after short -term intensive insulin therapy. The blood pressure was not significantly changed. Conclusion Tight glyeemic control through intensive insulin therapy helps to decrease the excretion of urinary albumin.

关 键 词：糖尿病肾病 微量清蛋白尿 胰岛素强化治疗 

分 类 号：R587.1[医药卫生—内分泌]