骨髓微环境和骨髓增生异常综合征的研究进展  

Progress in Research of Bone Marrow Microenvironment and Myelodysplastic Syndromes

作　　者：韩丹壘[1] 郭静明[1] 

机构地区：[1]三峡大学第一临床医学院,湖北省宜昌市443000

出　　处：《中国全科医学》2012年第21期2375-2377,共3页Chinese General Practice

摘　　要：骨髓微环境是一个由非造血细胞、造血干细胞以及细胞外基质和多种细胞因子等组成的复杂网状结构,其各成分相互作用以支持正常的造血。近来研究发现,许多血液恶性疾病的发生与骨髓微环境密切相关,已有小鼠模型证实了骨髓微环境在造血系统恶性疾病的始发和维持中起着重要作用,同时肿瘤细胞可以改变其周围的微环境以维持肿瘤细胞的生长。本文就骨髓微环境及其在骨髓增生异常综合征发生发展中的新进展进行综述。Objective Bone marrow microenvironment is a complex network structure consisting of non-hematopoietic cells,hematopooietic stem cells,extracellular matrix and various cytokines.Its components interact to support normal hematopoiesis.Recent researches find that the generation of many diseases is closely related to bone marrow microenvironment.Mouse models have confirmed that bone marrow microenvironment plays an important role in the original generation and maintenance of malignant diseases of hematopoietic system,and that the interaction of tumor cells and matrix can change microenvironment to maintain the growth of tumor cells.This paper reviews the new progress in research of bone marrow microenvironment and its role in generation and development of myelodysplastic syndromes.

关 键 词：骨髓微环境 骨髓增生异常综合征 细胞因子类 

分 类 号：R551.3[医药卫生—血液循环系统疾病]