β-七叶皂苷钠联合甘露醇治疗重型颅脑损伤的疗效观察  

Clinical Study on the Efficacy of β-Aescine Sodium Combined with Mannitol in the Treatment of Severe Brain Injury

作　　者：邓元央[1] 黄海能[1] 韦桂源[1] 黄华东[1] 罗起胜[1] 符黄德[1] 李传玉[1] 

机构地区：[1]广西右江民族医学院附属医院神经外科,广西百色市533000

出　　处：《中国全科医学》2012年第21期2484-2486,共3页Chinese General Practice

基　　金：广西卫生厅科研立项课题(Z2010088)

摘　　要：目的探讨β-七叶皂苷钠联合甘露醇治疗重型颅脑损伤的临床疗效。方法将我院2009年6月—2011年6月收治的60例重型颅脑损伤患者随机分为治疗组(30例)及对照组(30例),对照组给予20%甘露醇、营养神经及预防感染等常规治疗,治疗组在此基础上加用β-七叶皂苷钠进行降颅内压(ICP)治疗,比较两组治疗后ICP及治疗前后格拉斯哥昏迷评分(GCS)变化情况,并于治疗后3、6个月进行格拉斯哥预后评分(GOS)。结果治疗组治疗后ICP及GCS与对照组比较,差异有统计学意义(P<0.05);治疗后3个月及6个月两组GOS比较,差异均有统计学意义(P<0.05)。结论β-七叶皂苷钠与甘露醇联合应用治疗重型颅脑损伤可起到理想效果,两药合用不仅能够明显降低颅内压,而且对早期GCS及远期GOS都有明显改善。Objective To study the clinical efficacy of β-aescine sodium combined with mannitol in the treatment of severe brain injury.Methods 60 patients with severe brain injury admitted to our hospital from June 2009 to June 2011 were randomly divided into treatment group（30 cases） and control group（30 cases）.The control group was routinely given 20% mannitol,neurotrophic and anti-infection treatment.While the treatment group was given β-aescine sodium in addition to reduce intracranial pressure（ICP）.The ICP before the treatment and Glasgow Coma Scale（GCS） before and after the treatment of the two groups were compared.Glasgow Outcome Scale（GOS） was conducted three and six months after treatment respectively.Results The ICP and GCS in the treatment group showed statistically significant differences compared with control group after treatment（P〈0.05）.The three-month and six-month after treatment showed that the difference of GOS between treatment group and control group was also statistically significant（P〈0.05）.Conclusion The efficacy of β-aescine sodium combined with mannitol in the treatment of severe brain injury is satisfactory,can significant reduce the intracranial pressure,and improve the results of short-term GCS and long-term GOS.

关 键 词：β七叶皂苷钠 甘露醇 颅脑损伤 治疗结果 

分 类 号：R651.15[医药卫生—外科学]