高血压患者脉压差变化与CRP、ET-1的相关性  

Study on Correlation between Pulse Presssure and CRP, ET-1 in Hypertensive Patients

作　　者：刘镇[1] 曾纪斌[1] 古春花[1] 宋银枝[1] 钟慧红[1] 彭智勇[1] 叶仁群[1] 郭玉花[1] 

机构地区：[1]广东省深圳市宝安区中医院,广东深圳518133

出　　处：《临床医学工程》2012年第8期1280-1281,共2页Clinical Medicine & Engineering

基　　金：深圳市宝安区科技局课题(编号:2009339)

摘　　要：目的探讨高血压患者脉压差(PP)变化与高敏C反应蛋白(hs-CRP)、ET-1的相关性。方法选择2009年10月至2011年8月在我院心内科住院的1～3级高血压患者共240例按脉压分成4组,<50mmHg(A组),50～60mmHg(B组),61～70mmHg(C组),>70mmHg(D组),同时选60例健康志愿者作为对照组,按标准方法测定PP,并检测其血中hs-CRP、ET-1的含量,分析三者的关系。结果在校正了平均血压及其他相关因素后,回归分析表明,PP与hs-CRP、ET-1均呈正相关。结论高血压患者的PP与hs-CRP、ET-1密切相关,推测炎症可能是增加血压变异性的一个独立危险因子。Objective To explore the correlation between pulse presssure （PP） and CRP, ET-1 in hypertensive patients. Methods 240 patients with hypertension were divided into 4 groups according to the pulse pressure： group A （〈50 mm Hg）, group B （50 - 60 mm Hg）, group C （61 - 70 mm Hg） and group D （〉70 mm Hg）. 60 healthy volunteers were selected as the control group. The PP, serum content of hs-CRP and ET-1 were detected, and the relationships among them were analyzed. Results Regression analysis after adjustment of average blood pressure and other related factors showed positive correlation between PP and hs-CRP, ET-1. Conclusions Pulse presssure is related to hs-CRP and ET-1 in patients with hypertension. Inflammation may be an independent risk factor for increased blood pressure variability.

关 键 词：高血压 脉压差 hs—CRP ET-1 

分 类 号：R544.1[医药卫生—心血管疾病]