小剂量孕激素在单纯性子宫内膜增生治疗中的应用  

The Clinical Observation on the Management of Cndometrial Simple Hyperplasia by Small Doses of Progesterone

作　　者：杨志海[1] 肖祯[1] 于虹[1] 

机构地区：[1]大连医科大学附属第一医院,辽宁大连116011

出　　处：《中国医学创新》2012年第22期22-23,共2页Medical Innovation of China

摘　　要：目的:探讨小剂量孕激素对单纯性子宫内膜增生患者的临床症状、子宫内膜情况的影响。方法:选取2009年10月-2011年6月病理诊断为子宫内膜单纯增生患者76例,于分段诊刮术后第15天及下两次月经周期第15天给予小剂量孕激素治疗10d,共3个周期,观察经期、月经周期、子宫内膜变化。结果:小剂量孕激素治疗后患者月经周期明显规律,经期逐渐缩短,月经量明显减少,经期前子宫内膜厚度变薄,与治疗前比较差异具有统计学意义(P<0.05);治疗后增殖期子宫内膜6例(7.9%),分泌期子宫内膜66例(86.8%),仍为单纯型增生者4例(5.3%),转化率为94.7%(72/76);治疗后多数患者无不良反应。结论:3个月的小剂量孕激素可有效治疗子宫内膜单纯型增生。Objective： To observe and analyze the effectiveness and safety of the management of endometrial simple hyperplasia by small doses of progesterone.Method：76 cases of endometrial hyperplasia diagnosed by pathologieal examination were treated with small doses of progesterone from the 15th day to 25th day after curettage and the next two menstrual cycles. Menstrual duration, interval between periods were observed. The pathology and thickness of endometrium were detected after the sixth menstruation.Result：After three periods treatment small doses of progesterone, the menstrual cycle obvious rule, the menstrual duration shortened obviously, Before the period endometrial thickness thin. Difference had statistics significance （P〈0.05）. After treatment, 6 cases（7.9%）of proliferative endometrium, 66 cases（86.8%）of secretory phase endometrium and 4 cases（5.3%）of simple hyperplasia were detected by curettage followed pathological diagnosis. Conclusion ：Three months treatment by small doses of progesterone is aneffective method for endometrial simple hyperplasia.

关 键 词：功血 单纯性子宫内膜增生 孕激素 

分 类 号：R711.7[医药卫生—妇产科学]