丹参酮ⅡA磺酸钠联合低分子肝素治疗不稳定型心绞痛Meta分析  

Sodium Tanshinone ⅡA Sulfonate Combined with Low Molecular Weight Heparin in Treating Unstable Angina:A Meta-analysis

作　　者：赵劲波[1] 李元红 江洪[1] 

机构地区：[1]武汉大学人民医院心内科,武汉430060 [2]恩施土家族苗族自治州中心医院心内科,湖北恩施土家族苗族自治州445000

出　　处：《临床误诊误治》2012年第8期76-79,共4页Clinical Misdiagnosis & Mistherapy

摘　　要：目的评价丹参酮ⅡA磺酸钠联合低分子肝素治疗不稳定型心绞痛的效果。方法计算机检索中国学术期刊网络出版总库、CNKI(1994—2011)、万方医学数据库(1999—2011)、维普中文科技期刊全文数据库(1989—2011年)中关于丹参酮ⅡA磺酸钠联合低分子肝素治疗不稳定型心绞痛的随机对照试验,对符合标准的随机对照试验进行Meta分析。结果共命中7篇符合条件文献。Meta分析结果显示,治疗2周后试验组疗效优于对照组,总效应Z=6.12(P<0.00001),OR及其95%可信区间4.48(2.77,7.24),其中3项研究对心电图进行评价,治疗2周后心电图改善情况试验组亦显著优于对照组,总效应Z=3.80(P=0.0001),OR及其95%可信区间2.83(1.65,4.84)。结论不稳定型心绞痛患者在常规治疗基础上联合应用丹参酮ⅡA磺酸钠和低分子肝素可明显改善心绞痛症状,有效控制心绞痛发作。Objective To evaluate the effectiveness of Sodium Tanshinone ⅡA Sulfonate combined with Low Molecular Weight Heparin in treating unstable angina （UA）. Methods We conducted Meta-analysis by the randomized controlled trails （RCT） for patients with Sodium Tanshinone ⅡA Sulfonate combined with Low Molecular Weight Heparin in treating unstable angina （UA） from CNKI database （ 1994-2012）, Wan Fang medicine database （ 1999-2012）, VIP full-text data base （1989-2012） and Medline. Results There were 7 trials. After two weeks treatment Meta-analysis indicated that the curative effect of combination therapy was better than that of regular group in treating angina pectoris. The total effect was Z = 6.12 （P 〈 0.0（0301 ）, and the total effect of therapy group was better than that of control group [ OR = 4.48, 95% CI （2.77, 7.24）, P 〈 0. 00001 ]. Three items showed that the curative efficiency and significant efficiency in the improvement of electrocardiogram were dramatically better than that of control group, and the total effect was Z -3.80 [ OR = 2.83, 95% CI （1.65, 4.84） ]. Conclusion This Meta-analysis showed that the treatment of Sodium Tanshinone HA Sulfonate combined with Low Molecular Weight Heparin in treating unstable angina （UA） can obviously improve symptoms and effectively control angina pectoris attacks. [Key words]

关 键 词：丹参酮 肝素 低分子量 心绞痛 不稳定型 META分析 

分 类 号：R541.42[医药卫生—心血管疾病]