干燥综合征患者干眼病的临床分析  

The clinical analysis of dry eye in patients with primary Sj^gren＇s syndrome

作　　者：张玉明[1] 王芳芳[1] 李宝贞[2] 何艳[1] 彭燕一[1] 

机构地区：[1]桂林医学院附属医院眼科,541001 [2]桂林医学院附属医院眼科风湿免疫科,541001

出　　处：《中华风湿病学杂志》2012年第8期523-526,F0003,共5页Chinese Journal of Rheumatology

基　　金：广西壮族自治区卫生厅自筹经费科研课题（Z2010307）

摘　　要：目的探讨原发性干燥综合征（pSS）患者干眼病的临床特点。方法回顾性分析2009年8月至2011年8月在我院风湿免疫科住院并确诊为pSS的96例患者的干眼病诊断性检查数据。结果在96例患者中：①干眼症状明显的患者达到89例，其中23例有2种以上的干眼症状；②泪膜破裂时间（BUT）检查〈5s的154只眼，5．10S的18只眼，〉10S的20只眼，平均（3．7±1．9）s；③泪河高度：〈0．3mm的154只眼，平均（0．21±0．10）mm；④Van Bijsterveld角膜荧光素染色评分：平均得分为5．2±2．4；⑤SchirmerⅠ试验：192只眼滤纸湿长均〈10mm／5min，平均为（4．6±1．8）mm；⑥睑板腺功能评分：平均1．5±0．9。结论pSS患者的泪河宽度降低、SchirmerⅠ试验滤纸湿长减少，泪液分泌量减少；同时BUT缩短、伴有睑板腺功能障碍。pSS所致的干眼病是一种混合型的干眼病。Objective To study the ciinic-al characteristics of primary Sjtigren＇ s syndrome （pSS） patients with dry eyes. Methods Ninety-six pSS patients with dry eyes admitted to the Department of Rheumatology and Immunology, the Affiliated Hospital of Guilin Medical College from August 2009 to August 2011 were retrospectively analyzed. Results In all 96 patients, 89 patients had symptoms, 23 of whom had two or more symptoms. The tear-film break-up time （BUT） of 154 eyes were Less than 5 seconds, 18 were between 5-10 second, and twenty were more than 10 seconds, with the average of 3.7±1.9 seconds. The length of tear flow of 154 eyes＇width of tear mocus was less than 3 millimetres （mm）, with the average of （0.21±0.10） mm. The average score of corneal fluorescein staining score was 5.2±2.4. The wet lengths of filter paper of 192 eyes were all less than 10 mm/5 min, with the average of （4.6±1.8） mm. The average score of meibomian gland function was 1.5±0.9. Conclusion In patients with pSS, the width of tear meniscus and the wet lengths of filter paper are reduced, which implies less tear secretion. At the same time, BUTs are short, and the Meibomian gland dysfunction are observed. Dry eyes of pSS are mixed in type, not only aqueous tear deficiency.

关 键 词：干燥综合征 干眼病 回顾性研究 

分 类 号：R593[医药卫生—内科学]