老年早期糖尿病肾病相关危险因素分析  

Relative risk factors analysis of elderly early phase diabetic nephropathy

作　　者：李文静[1] 秦爱平[1] 廖斌[1] 

机构地区：[1]湖南省马王堆医院内分泌科,湖南长沙410004

出　　处：《中国当代医药》2012年第22期59-60,63,共3页China Modern Medicine

摘　　要：目的探讨老年2型糖尿病微量清蛋白尿与相关危险因素的关系。方法将150例老年2型糖尿病患者分为合并微量清蛋白尿(MAU)组(76例)与正常微量清蛋白尿(NAU)组(74例),检测两组体重指数(BMI)、血糖、血脂、胰岛素、肌酐(Cr)、尿酸(UA)、糖化血红蛋白(HbA1c)、超敏C反应蛋白、颈动脉内膜中层厚度(CIMT)等,计算胰岛素抵抗指数(HOMA-IR),并进行比较。结果 MAU组收缩压(SBP)、舒张压(DBP)、UA、Cr、三酰甘油(TG)、空腹血糖(FPG)、HbA1c、空腹胰岛素(FINS)、HOMA-IR、CIMT明显高于NAU组(P<0.05)。MAU组HDL低于NAU组(P<0.05)。直线相关性分析显示MAU与UA、TG、、HOMR-IR、空腹血糖、HbA1c、CIMT呈正相关,与HDL呈负相关。结论老年T2DM合并MAU与高血糖、高血压、血脂代谢紊乱、胰岛素抵抗有关,更易发生大血管病变。Objective To investigate relationship between microalbuminuria and relative risk factors in elderly type 2 diabetes. Methods One hundred and fifty elderly type 2 diabetic patients were divided into two groups： microalbuminuria （MAU） group （76 cases） and normoalbuminuria（NAU） group （74 cases）. Body mass index（BMI）, blood glucose, blood lipid, serum insulin, creatinine （Cr）, uric acid （UA）, glycosylated hemoglobin （HbAlc）, high sensitivity C-reactive protein, carotid artery intima-media thickness （CIMT） of two groups were examined. Insulin resistance index of the two groups were calcu- lated and compared. Results The level of systolic blood pressure（SBP）, diastolic blood pressure（DBP）, UA, Cr, triglyceride （TG）, fasting plasma glucose （FPG）, HbA,c, fasting insulin （FINS）, HOMA-IR, CIMT in type 2 diabetic patients with MAU were higher than those of type 2 diabetic patients with NAU （P 〈 0.05）. The level of HDL in type 2 diabetic patients with MAU were lower than that of subjects with NAU （P 〈 0.05）. Conclusions Elderly type 2 diabetic patients with MAU are related with hyperglycemia,hypertension, dyslipidemia, insulin resistance and are easy to occur macro vascular lesions.

关 键 词：糖尿病肾病 老年 危险因素 早期 

分 类 号：R587.1[医药卫生—内分泌]