新诊断2型糖尿病患者亚临床大血管病变及危险因素分析  

Prevalence and risk factors of sub-clinical large vessel disease in patients with newly diagnosed type 2 diabetes

作　　者：周斌[1] 蒋晓真[1] 陈蕊华[1] 顾哲[1] 顾佩莉[1] 朱震宏[1] 徐凌燕[1] 邹宇峰[1] 秦玉兰[1] 

机构地区：[1]上海市浦东新区人民医院内分泌科,上海201200

出　　处：《内科理论与实践》2012年第4期297-299,共3页Journal of Internal Medicine Concepts & Practice

基　　金：上海市卫生局科研项目(项目编号:2009214);浦东新区科技发展基金项目(项目编号:PKJ2010-Y25)

摘　　要：目的:研究新诊断2型糖尿病患者的亚临床大血管病变患病情况及危险因素分析。方法 :采取社区筛查、门诊收集的方法,获取178例新诊断2型糖尿病患者,行颈动脉彩色超声筛查亚临床大血管病变,并采集个人史、既往史、身高、体重、腰围及糖化血红蛋白(HbA1c)、血脂等数据。结果:178例患者中合并亚临床大血管病变者(A组)67例,患病率为37.6%,无亚临床大血管病变者(B组)111例(62.4%)。A组患者年龄较大,高血压患病率较高,且2组间高血压病程、收缩压差异具有统计学意义(P<0.05)。2组患者性别比例、吸烟率相似,腰围、腰臀比、舒张压、HbA1c、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇无明显差异,A组体质量指数(BMI)、总胆固醇(TC)水平较B组升高(P<0.05)。Logistic回归分析显示,高血压病史、BMI、TC是亚临床大血管病变患病的危险因素(P<0.05)。结论:部分新诊断2型糖尿病患者已合并亚临床大血管病变,高血压病程、BMI、TC是其患病的危险因素。Objective To study the prevalence and risk factors of sub-clinical large vessel disease in patiens with newly diagnosed type 2 diabetes（T2DM）. Methods The patients（n=178） with newly diagnosed T2DM were divided into two groups according to results of carotid artery color uhrasonography. Data of present history, past history, height, weight, waist circumference , hemoglobin Alo（HbAc）, and serum lipid level were collected. Results Group A （n=67） had sub- clinical large vessel disease and group B （n=111） had no sub-clinical large vessel disease. There were significant differences in prevalence of hypertension, duration of hypertension, systolic blood pressure, the body mass index （BMI）, total cholesterol （TC） between group A and group B （P〈0.05）, and no significant differences in gender, smoking ,waist circumference, waist-hip ratio, diastolic blood pressure, HbAlc, triglyceride, high density lipoprotein cholesterol and low density lipoprotein cholesterol were found between group A and group B. Logistic regression analysis revealed that hypertension, BMI, TC were associated with risk of sub-clinical large vessel disease （β=1.370, P〈0.05）. Conclusions Duration of hypertension, BMI and TC were the risk factors of sub-clinical large vessel disease in patients with newly diagnosed T2DM.

关 键 词：部分2型糖尿病 亚临床大血管病变: 危险因素 

分 类 号：R587.1[医药卫生—内分泌]