生精片对男性少弱精子症患者精液参数的影响及作用机制研究  被引量:20

Shengjing prescription improves semen parameters of oligoasthenozoospermia patients:Efficacy and mechanism

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作  者:孙振高[1] 连方[1] 姜鲲鹏[1] 张建伟[2] 马凤梅[2] 张宁[2] 孙金龙[1] 杨武文[1] 

机构地区:[1]山东中医药大学附属医院生殖中心,山东济南250011 [2]山东中医药大学临床学院,山东济南250014

出  处:《中华男科学杂志》2012年第8期764-767,共4页National Journal of Andrology

基  金:国家自然科学基金(30901920);山东省自然科学基金(Q2008C17);山东省中医药科技发展计划项目(2009-038)~~

摘  要:目的:观察生精片治疗男性少弱精子症患者的临床有效性,并对其作用机制进行探讨。方法:选取少弱精子症患者120例,采取随机对照研究的方法,治疗组口服生精片,对照组服用维生素E,服用12周后,观察治疗前后两组精子浓度、精子活力及正常形态精子百分率,血清FSH、T、LH水平,DNA碎片指数,低渗肿胀精子百分率,精浆弹性蛋白酶、α-葡糖苷酶、精子顶体酶、果糖及精浆锌等指标变化。结果:生精片能显著改善精子浓度、活力和形态(P<0.01),血清FSH水平明显降低,T明显升高(P<0.01),DNA碎片指数明显降低,低渗肿胀精子百分率显著升高,弹性蛋白酶明显降低,α-葡糖苷酶、精子顶体酶、果糖、精浆锌等水平明显升高。结论:生精片通过多层次、多环节、多途径改善少弱精子症患者的精液参数,具有良好的临床疗效。Objective: To investigate the clinical efficacy of Shengjing prescription for oligoasthenozoospermia and its action mechanism. Methods: We equally assigned 120 patients with oligoasthenozoospermia to receive Shengjing prescription (treatment group) and vitamin E (control group), respectively, for 12 weeks. Before and after the treatment, were obtained sperm concentration, sperm motility, the percentage of morphologically normal sperm, the levels of serum follicle - stimulating hormone ( FSH), testosterone (T) and luteinizing hormone (LH), sperm DNA fragmentation index (DFI), the percentage of hypotonic swelling sperm, and the levels of seminal plasma elastase, α-glucosidase, fructose, zinc and acrosin. Results: Compared with vitamin E, Shengfing prescription significantly improved sperm concentration, motility and morphology (P 〈0.01 ), decreased the serum FSH level, elevated the serum T level (P 〈 0.01 ), reduced DFI and seminal plasma elastase, and increased the percentage of hypotonic swelling sperm as well as the levels of seminal plasma α-glucosidase, fructose, zinc and acrosin. Conclusion : Shengjing prescription improves semen parameters of patients with oligoasthenozoospermia at multiple levels and through multiple channels.

关 键 词:生精片 少弱精子症 精液参数 机制 

分 类 号:R698.2[医药卫生—泌尿科学]

 

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