壳聚糖-磷酸三钙复合材料的动物相容性评价  

Chitosan/tricalcium Phosphate Composite Material Celluar Biocompatibility and its Safety Evaluation by Animal Experiments

作　　者：李珊[1] 闫雪萍[1] 庾佳佳[2] 聂敏[1] 

机构地区：[1]兰州大学口腔医院口腔内科,甘肃兰州730000 [2]兰州大学第二临床医学院骨科

出　　处：《口腔医学研究》2012年第8期780-782,共3页Journal of Oral Science Research

基　　金：中央高校小额探索项目(代码:223000-860164)

摘　　要：目的:通过壳聚糖、磷酸三钙的复合制备一种具有较好生物相容性和生物可降解性的组织工程支架材料。方法:采用冷冻干燥法将2种材料复合成具有较高孔隙率的复合材料,对此材料进行动物实验以评价其生物安全性。结果:壳聚糖/磷酸三钙与肌肉组织可以形成紧密的结合,降解较快。结论:壳聚糖/磷酸三钙复合材料在生物学评价实验中符合评价标准,可用作组织工程支架的基质材料。Objective： To compound chitosan with calcium phosphate which has good biocompatibility and is a biodegradable scaffold for tissue engineering. Methods： Freeze-drying method using two materials with high porosity combined into a composite material, the compatibility of this material for animal studies to evaluate the biological safety. Results： Chitosan/tricalcium phosphate and muscle tissue can integrated closely, and the material has a rapid degradation. Conclusion： Chitosan/tricalcium phosphate composite meet evaluation criteria, and the matrix can be used as tissue engineering scaffold material.

关 键 词：壳聚糖磷酸三钙 生物相容性 

分 类 号：R318.08[医药卫生—生物医学工程]